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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the


Securities Exchange Act of 1934

Filed by the Registrant  ☒                             Filed by a Party other than the Registrant  ☐

Filed by the Registrant
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Filed by a Party other than the Registrant
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Check the appropriate box:

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Preliminary Proxy Statement
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Confidential, for Use of the Commission Only (as permitted by Rule14a-6(e) 14a­6(e)(2))
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Definitive Proxy Statement

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Definitive Additional Materials
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Soliciting Material Pursuant to §240.14a-12under §240.14a­12

PROTEOSTASIS

YUMANITY THERAPEUTICS, INC.



(Exact name of registrant as specified in its charter)

(Name of Registrant as Specified In Its Charter)

Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box)

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No fee required.
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Fee computed on table below per Exchange Act Rules14a-6(i)(4) 14a­6(i)(1) and0-11. 0­11.
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Fee paid previously with preliminary materials.
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Check box if any part of the fee is offset as provided by Exchange Act Rule0-11(a) 0­11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.
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LOGO

80

40 Guest Street,

Suite 500

4410

Boston, Massachusetts 02135

NOTICE OF 20202021 ANNUAL MEETING OF STOCKHOLDERS


To be held on June 29, 2020

2, 2021

To the Stockholders of ProteostasisYumanity Therapeutics, Inc.:

NOTICE IS HEREBY GIVEN that the 20202021 Annual Meeting of Stockholders (the “Annual Meeting”) of ProteostasisYumanity Therapeutics, Inc., a Delaware corporation (the “Company”) will be held on Monday, June 29, 2020,2, 2021, at 9:00 a.m. Eastern Time at 80 Guest Street, First Floor, Event Room, Boston, Massachusetts 02135 forTime. To protect the following purposes:

health and safety of our stockholders, employees, directors and community in light of the COVID-19 pandemic, this year’s Annual Meeting will be held virtually. You may attend the virtual Annual Meeting by visiting www.virtualshareholdermeeting.com/YMTX2021, where you will be able to vote electronically and submit questions. You will need the 16-digit control number included with the Notice of Internet Availability of Proxy Materials being mailed to you separately in order to attend the Annual Meeting.
The purpose of the Annual Meeting is the following:
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To elect the three (3) Class IIIII directors, Meenu Chhabra, Jeffery W. Kelly,N. Anthony Coles, M.D., Kim C. Drapkin and Lynne Zydowsky, Ph.D. and David Arkowitz,, to serve until the 20232024 Annual Meeting of Stockholders and until their successors are duly elected and qualified, subject to their earlier resignation or removal;

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To ratify the appointment by the Audit Committee of the Board of Directors of PricewaterhouseCoopers LLP as the Company’sour independent registered public accounting firm for the fiscal year ending December 31, 2020;2021; and

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To transact such other business as may properly come before the stockholders at the Annual Meeting or at any and all adjournments or postponements thereof.

These items of business are more fully described in the Proxy Statement accompanying this Notice.

The Board of Directors has fixed the close of business on April 30, 20209, 2021 as the record date for determining stockholders entitled to notice of and to vote at the Annual Meeting or any adjournment or postponement thereof.

We are pleased to take advantage of Securities and Exchange Commission rules that allow companies to furnish their proxy materials over the Internet. We are mailing to our stockholders of record and beneficial owners as of the record date a Notice of Internet Availability of Proxy Materials instead of a paper copy of our proxy materials and our 2019 Annual Report on Form10-K. 10-K for the fiscal year ended December 31, 2020 (the “2020 Annual Report on Form 10-K”). The Notice contains instructions on how to access those documents and to cast your vote via the Internet or by telephone.Internet. The Notice also contains instructions on how to request a paper copy of our proxy materials and our 20192020 Annual Report on Form10-K. All stockholders who do not receive a Notice will receive a paper copy of the proxy materials and the 20192020 Annual Report on Form10-K by mail. This process allows us to provide our stockholders with the information they need on a more timely basis, while reducing the environmental impact and lowering the costs of printing and distributing our proxy materials.

To be admitted to the Annual Meeting and vote your shares, you must provide the 16-digit control number as provided described in the Notice, or proxy card, or voting instruction form at www.proxyvote.com. Please see the “General Information” section of the proxy statement that accompanies this notice for more details regarding the logistics of the virtual Annual Meeting, including the ability of stockholders to submit questions during the Annual Meeting, and technical details and support related to accessing the virtual platform.
Your vote is important. Whether or not you are able to attend the virtual Annual Meeting, in person, it is important that your shares be represented. To ensure that your vote is recorded promptly, please vote as soon as possible, even if you plan to attend the virtual Annual Meeting in person,Meeting. You may vote by submitting your proxy via the Internet, by telephone, or telephone as indicatedby mail (if you received paper copies of the proxy materials) by following the instructions on the proxy card or voting

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instruction card. Voting over the Internet or by signing, dating and returningtelephone, written proxy or voting instruction card will ensure your representation at the proxy card.

We intend to hold ourvirtual Annual Meeting in person. However, we are actively monitoring the global COVID-19 coronavirus pandemic; we are sensitive to the public health and travel concerns our stockholders may have and the protocols that federal, state, and local governments may impose. As a result, we may decide to hold the Annual Meeting in a different location or solely by meansregardless of remote communication (i.e., a virtual-only meeting). Please retain the control numbers from your proxy card so thatwhether you can access the Annual Meeting if it is converted to a virtual-only meeting. Any such change will be announced via a press release that will be filed as additional soliciting material with the Securities and Exchange Commission as soon as reasonably practicable before the Annual Meeting.

attend.

By Order of the Board of Directors,

LOGO

Meenu Chhabra



/s/ Richard Peters, M.D., Ph.D.

Richard Peters, M.D., Ph.D.
President, Chief Executive Officer and Director

Boston, Massachusetts

April 29, 2020

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GENERAL INFORMATION ABOUT THESE PROXY MATERIALS AND VOTING

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OVERVIEW OF PROPOSALS

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PROPOSAL 1 ELECTION OF DIRECTORS

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PROPOSAL 2 RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

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EXECUTIVE OFFICERS

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CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS

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CORPORATE GOVERNANCE

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EXECUTIVE COMPENSATION

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EQUITY COMPENSATION PLAN INFORMATION

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DIRECTOR COMPENSATION

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HOUSEHOLDING OF PROXY MATERIALS

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STOCKHOLDER PROPOSALS
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OTHER MATTERS

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PROTEOSTASIS

YUMANITY THERAPEUTICS, INC.


40 Guest Street, Suite 4410
Boston, Massachusetts 02135
PROXY STATEMENT


FOR THE 20202021 ANNUAL MEETING OF STOCKHOLDERS


TO BE HELD ON JUNE 29, 2020

AT 9:00 AM

GENERAL INFORMATION ABOUT THESE PROXY MATERIALS AND VOTING

Who is soliciting my vote?

We are providing you with these2, 2021

This proxy materials becausestatement contains information about the Board of Directors (the “Board of Directors”) is soliciting your proxy to vote at the 20202021 Annual Meeting of Stockholders, (the “Annual Meeting”)or the Annual Meeting, of ProteostasisYumanity Therapeutics, Inc. (the “Company”), including at any adjournments or postponements thereof, towhich will be held on Monday,Wednesday, June 29, 2020,2, 2021 at 9:00 a.m. Eastern Time at 80 Guest Street, First Floor, Event Room, Boston, Massachusetts 02135.

Do I need toTime. To protect the health and safety of our stockholders, employees, directors and community in light of the COVID-19 pandemic, this year’s Annual Meeting will be held virtually. You may attend the virtual Annual Meeting to vote?

You are invited to attend the Annual Meetingby visiting www.virtualshareholdermeeting.com/YMTX2021, where you will be able to vote on the proposals described inelectronically and submit questions. The Board of Directors of Yumanity Therapeutics, Inc. is using this proxy statement (the “Proxy Statement”). However, you do not need to attend the Annual Meeting to vote your shares. Instead, you may simply follow the instructions below to submit your proxy over the telephone, through the Internet or by mail, and your votes will be castsolicit proxies for youuse at the Annual Meeting. The proxy materials, including this Proxy Statement and our Annual Report on Form10-K for the year ended December 31, 2019, are being distributed and made available on or about May 20, 2020.

In this Proxy Statement,proxy statement, the terms “Proteostasis,“Yumanity,” “Company,” “we,” “us,” “our” and “Company”“our” refer to ProteostasisYumanity Therapeutics, Inc. The mailing address of our principal executive offices is Proteostasis40 Guest Street, Suite 4410, Boston, Massachusetts 02135.

All properly submitted proxies will be voted in accordance with the instructions contained in those proxies. If no instructions are specified, the proxies will be voted in accordance with the recommendation of our Board of Directors with respect to each of the matters set forth in the accompanying Notice of Meeting. You may revoke your proxy at any time before it is exercised at the meeting by giving by giving our corporate secretary written notice to that effect.
We made this proxy statement and our Annual Report on Form 10-K for the fiscal year ended December 31, 2020, or the 2020 Annual Report on Form 10-K, available to stockholders on April 22, 2021.
We are an “emerging growth company” under applicable federal securities laws and therefore permitted to conform with certain reduced public company reporting requirements. As an emerging growth company, we provide in this proxy statement the scaled disclosure permitted under the Jumpstart Our Business Startups Act of 2012, or the JOBS Act, including the compensation disclosures required of a “smaller reporting company,” as that term is defined in Rule 12b-2 promulgated under the Securities Exchange Act of 1934, as amended, or the Exchange Act. In addition, as an emerging growth company, we are not required to conduct votes seeking approval, on an advisory basis, of the compensation of our named executive officers or the frequency with which such votes must be conducted. We will remain an “emerging growth company” until the earliest of (i) December 31, 2021; (ii) the last day of the fiscal year in which our total annual gross revenue is equal to or more than $1.07 billion; (iii) the date on which we have issued more than $1 billion in nonconvertible debt during the previous three years; or (iv) the date on which we are deemed to be a large accelerated filer under the rules of the Securities and Exchange Commission, or SEC. Even after we are no longer an “emerging growth company,” we may remain a “smaller reporting company.”
Important Notice Regarding the Availability of Proxy Materials for
the Annual Meeting of Stockholders to be Held on June 2, 2021:
This proxy statement and our 2020 Annual Report on Form 10-K are
available for viewing, printing and downloading at www.proxyvote.com.
A copy of our Annual Report on Form 10-K for the fiscal year ended December 31, 2020, as filed with the SEC, except for exhibits, will be furnished without charge to any stockholder upon written request to Yumanity Therapeutics, Inc., 8040 Guest Street, Suite 500,4410, Boston, Massachusetts 02135.02135, Attention: Corporate Secretary. This proxy statement and our Annual Report on Form 10-K for the fiscal year ended December 31, 2020 are also available on the SEC’s website at www.sec.gov, or on our website at www.yumanity.com/investor-relations/financial-information/.

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YUMANITY THERAPEUTICS, INC.
PROXY STATEMENT
FOR THE 2021 ANNUAL MEETING OF STOCKHOLDERS
TO BE HELD ON JUNE 2, 2021
AT 9:00 AM
GENERAL INFORMATION ABOUT THESE PROXY MATERIALS AND VOTING
When is this proxy statement and the accompanying materials scheduled to be sent to stockholders?
We have elected to provide access to our proxy materials to our stockholders via the Internet. Accordingly, on or about April 22, 2021, we will begin mailing a Notice of Internet Availability of Proxy Materials, or Notice. Our proxy materials, including the Notice of the 2021 Annual Meeting of Stockholders, this proxy statement and the accompanying proxy card or, for shares held in street name (i.e., held for your account by a broker or other nominee), a voting instruction form, and the 2020 Annual Report on Form 10-K will be mailed or made available to stockholders on the Internet on or about the same date.
Why did I receive a notice regarding the availabilityNotice of proxy materials on the Internet Availability of Proxy Materials instead of a full set of proxy materials?

Pursuant to rules adopted by the Securities and Exchange Commission, (the “SEC”),or SEC, for most stockholders, we are providing access to our proxy materials over the Internet rather than printing and mailing theour proxy materials. We believe electronic deliveryfollowing this process will expedite the receipt of such materials and will help lower our costs and reduce the environmental impact of our annual meeting materials. Accordingly, we are sending aTherefore, the Notice of Internet Availability of Proxy Materials (the “Notice”)was mailed to our stockholdersholders of record and beneficial owners as of the record date identified below.

our common stock starting on or about April 22, 2021. The Notice will provideprovides instructions as to how youstockholders may access and review theour proxy materials, including the Notice of the 2021 Annual Meeting of Stockholders, this proxy statement, the proxy card and our 2020 Annual Report onForm 10-K, on the website referred to in the Notice or, alternatively, how to request that a copy of the proxy materials, including a proxy card, be sent to youthem by mail. The Notice will also provideprovides voting instructions. In addition, stockholders of record may request to receive the proxy materials in printed form by mail or electronicallyby e-mail on an ongoing basis for future stockholder meetings. Please note that, while our proxy materials are available at the website referenced in the Notice, and our Notice of the 2021 Annual Meeting of Stockholders, this proxy statement and our 2020 Annual Report onForm 10-K are available on our website, no other information contained on either website is incorporated by reference in or considered to be a part of this document.

proxy statement.

Why are you holding a virtual Annual Meeting?
The safety of our stockholders is important to us and given the current guidance by public health officials surrounding COVID-19 and group gatherings, this year’s Annual Meeting will be a “virtual meeting” of stockholders. We intendhave implemented the virtual format in order to mailfacilitate stockholder attendance at our Annual Meeting. We have designed our virtual format to enhance, rather than constrain, stockholder access, participation and communication. For example, the Notice onvirtual format allows stockholders to communicate with us in advance of, and during, the Annual Meeting so they can ask questions of our Board of Directors or about May 20, 2020management.
How do I attend and participate in the annual meeting online?
To attend and participate in the Annual Meeting, stockholders will need to allaccess the live audio webcast of the meeting. To do so, stockholders of record entitledwill need to vote atvisit www.virtualshareholdermeeting.com/YMTX2021 and use their control number found on the Annual Meeting. The proxy materials, including the Notice of 2020 Annual Meeting of Stockholders, this Proxy

Statement and accompanying proxy card or for shares held in street name (held for your account by a broker or other nominee), voting instruction form, and the Annual Report onForm 10-K for the year ended December 31, 2019 will be made available to stockholders on the Internet on the same date.

Will I receive any other proxy materials by mail?

You will not receive any additional proxy materials via mail unless (1) you request a printed copy of the proxy materials in accordance with the instructions set forth in the Notice or (2) we elect, in our discretion, to send you a proxy card and a second Notice of Internet Availability of Proxy Materials, which we may sendand beneficial owners of shares held in street name will need to follow the same instructions.

You will need the 16-digit control number included on your proxy card or after May 30, 2020.

How do I attendNotice of Internet Availability of Proxy Materials, as applicable. Instructions on how to connect to the Annual Meeting?Meeting and participate via the Internet, including how to demonstrate proof of stock ownership, are posted at www.virtualshareholdermeeting.com/YMTX2021.If you do not have your 16-digit control number, you will be able to access and listen to the Annual Meeting but you will not be able to vote your shares or submit questions during the Annual Meeting.

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The live audio webcast of the Annual Meeting will be held on Monday, June 29, 2020,begin promptly at 9:00 a.m. Eastern Time. We encourage stockholders to login to this website and access the webcast before the Annual Meeting’s start time. Online check-in will begin, and stockholders may begin submitting written questions, at 8:45 a.m. Eastern Time, at 80 Guest Street, First Floor, Event Room, Boston, Massachusetts 02135. Directionsand you should allow ample time for the check-in procedures.
How can I get help if I have trouble checking in or listening to the meeting online?
We will have technicians ready to assist you with any technical difficulties you may have accessing the virtual meeting or submitting questions. If you encounter any difficulties accessing the virtual meeting during the check-in or meeting time, please call the technical support number that will be posted on the Virtual Shareholder Meeting log in page.
Who is soliciting my vote?
Our Board of Directors is soliciting your vote for the Annual Meeting may be found at www.proxydocs.com/pti. Information on howMeeting.
When is the record date for the Annual Meeting?
The record date for determination of stockholders entitled to vote in person at the Annual Meeting is discussed below.

the close of business on April 9, 2021.

How willCOVID-19 affect the Annual Meeting?

As of the printing of this Proxy Statement, we intend to hold our Annual Meeting in person. However, we are actively monitoring the global COVID-19 coronavirus pandemic; we are sensitive to the public health and travel concerns our stockholders may have and the protocols that federal, state, and local governments may impose. As a result, we may decide to hold the Annual Meeting in a different location or solelymany votes can be cast by means of remote communication (i.e., a virtual-only meeting). Please retain the control numbers from your proxy card so that you can access the Annual Meeting if it is converted to a virtual-only meeting. Any such change will be announced via a press release that will be filed as additional soliciting material with the Securities and Exchange Commission as soon as reasonably practicable, but in any event at least ten (10) days before the Annual Meeting.

IMPORTANT NOTICE REGARDING THE INTERNET AVAILABILITY OF PROXY MATERIALS FOR THE ANNUAL STOCKHOLDERS MEETING TO BE HELD ON JUNE 29, 2020:

This Proxy Statement, the accompanying proxy card or voting instruction card and our 2019 Annual Report on Form10-K are available at www.proxydocs.com/pti.

Stockholders Entitled to Vote; Record Date

The Board of Directors set April 30, 2020 as the record date. All record holdersall stockholders?

There were 10,193,831 shares of our common stock, par value $0.001 per share, asoutstanding on April 9, 2021, all of the close of business on that datewhich are entitled to vote with respect to all matters to be acted upon at the Annual Meeting. Each shareMeeting of common stock is entitled to one vote.the Stockholders on June 2, 2021, or the Annual Meeting. Each stockholder of record is entitled to one vote for each share of our common stock held by such stockholder. On April 27, 2020, there were 52,147,656None of our shares of commonundesignated preferred stock were outstanding and entitled to vote.

Quorum; Abstentions; BrokerNon-Votes

OurBy-laws provide that a majorityas of the shares entitled to vote, present in person or represented by proxy, will constitute a quorum for the transaction of business at the Annual Meeting. Under the General Corporation Law of the State of Delaware, shares that are voted “abstain” or “withheld” and broker“non-votes” are counted as present for purposes of determining whether a quorum is present at the Annual Meeting.

Under ourBy-laws, any proposal other than an election of directors is decided by a majority of the votes properly cast for and against such proposal, except where a larger vote is required by law or by our Certificate of Incorporation, as amended, or ourBy-laws, as amended. Any election of directors by our stockholders shall be determined by a plurality of the votes properly cast on the election of directors. Abstentions and broker

April 9, 2021.

“non-votes” are not included in the tabulation of the voting results on any such proposal and, therefore,How do not have the effect of votes in opposition to such proposals. A broker“non-vote” occurs when a nominee holding shares for a beneficial owner does not vote on a proposal because the nominee does not have discretionary voting power with respect to that particular item and has not received instructions from the beneficial owner.

Beneficial Owner: Shares Registered in the Name of a Broker or Bank

I vote?

If your shares were held, not in your name, but rather in an account at a brokerage firm, bank or other similar organization, then you are the beneficial owner of shares held in “street name” and the Notice is being forwarded to you by that organization. The organization holding your account is considered to be thea stockholder of record, there are several ways for purposes of voting at the Annual Meeting. As a beneficial owner, you have the right to direct your broker, bank or other agent regarding how to vote the shares in your account. If you do not give instructions to your brokerage firm, the brokerage firm will still be able to vote your shares with respect to certain “discretionary” items, but will not be allowed to vote your shares with respect toshares.
“non-discretionary” items. Proposal 1 is a“non-discretionary” item. If you do not instruct your broker how to vote with respect to Proposal 1, your broker may not vote for that proposal, and those votes will be counted as broker“non-votes.” Proposal 2 is considered to be a discretionary item, and your brokerage firm will be able to vote on this proposal even if it does not receive instructions from you. You are also invited to attend the Annual Meeting. However, since you are not the stockholder of record, you may not vote your shares in person at the Annual Meeting unless you request and obtain a valid proxy from your broker or other agent.

Voting

In Person

All stockholders of record as of the record date, or their duly appointed proxies, may attend the Annual Meeting in person; however, due to the evolvingCOVID-19 pandemic and related government guidelines, we urge our stockholders to monitor the applicable government guidelines and to not attend the Annual Meeting in person if the Massachusetts“stay-at-home” advisory remains in place on the date of the Annual Meeting, or if other applicable government guidelines continue to encourage people not to attend public gatherings. If you attend, you will be asked to present valid picture identification such as a driver’s license or passport. If your Proteostasis stock is held in a brokerage account or by a bank or other nominee, you are considered the beneficial owner of shares held in street name, and this Proxy Statement is being forwarded to you by your broker or nominee. As a result, your name does not appear on our list of stockholders. If your stock is held in street name, in addition to picture identification, you should bring with you a letter or account statement showing that you were the beneficial owner of the stock on the record date, in order to be admitted to the Annual Meeting. If you hold your shares through a bank or broker and wish to vote in person at the Annual Meeting, you must obtain a valid proxy from the firm that holds your shares.

By Proxy

If you do not wish to vote in person or will not be attending the Annual Meeting, youInternet. You may vote by proxy. You can vote by proxy over the Internetat www.proxyvote.com, 24 hours a day, seven days a week, by following the instructions at that site for submitting your proxy electronically. You will be required to enter the 16-digit control number provided inon your proxy card or voting instruction form. In order to be counted, proxies submitted by Internet must be received by the Notice,cutoff time of 11:59 p.m. Eastern Time on June 1.

By Telephone. You may vote using a touch-tone telephone by calling 1-800-690-6903, 24 hours a day, seven days a week. You will be required to enter the 16-digit control number provided on your proxy card or ifvoting instruction form. In order to be counted, proxies submitted by Internet must be received by the cutoff time of 11:59 p.m. Eastern Time on June 1.
By Mail prior to the Annual Meeting. If you requested printed copies of the proxy materials by mail, you can vote by mailing your proxy card as described in the proxy materials. Proxies submitted by mail must be received by the cutoff time of 11:59 p.m. Eastern Time on June 1.
During the Annual Meeting. If you attend the Annual Meeting online, you may vote your shares online while virtually attending the Annual Meeting by visiting www.virtualshareholdermeeting.com/YMTX2021. You will need your control number provided on your proxy card or Notice of Internet Availability of Proxy Materials in order to be able to vote during the Annual Meeting.
If you complete and submit your proxy before the Annual Meeting, the persons named as proxies will vote the shares represented by your proxy in accordance with your instructions. If you submit a proxy without giving voting instructions, your shares will be voted in the manner recommended by the Board of Directors on all matters presented in this proxy statement, and as the persons named as proxies may determine in their discretion with respect to any other matters properly presented at the Annual Meeting. You may also authorize another person or persons to act for you as proxy in a writing, signed by you or your authorized representative, specifying the details of those proxies’ authority. The original writing must be given to each of the named proxies, although it may be sent to them by electronic transmission if, from that transmission, it can be determined that the transmission was authorized by you. If
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Even if you complete and submitplan to participate in our virtual Annual Meeting, we recommend that you also vote by proxy so that your proxy beforevote will be counted if you later decide not to participate in the meeting, the persons named as proxies will vote the shares represented by your proxy in accordance with your instructions.Annual Meeting. If you submit a proxy without givingvia the Internet, by telephone, or by mail, your voting instructions your shares will be votedauthorize the proxy holders in the same manner recommendedas if you signed, dated, and returned your proxy card. If you submit a proxy via the Internet, by the Board of Directors on all matters presented in this Proxy Statement, and as the persons named as proxies may determine in their discretion with respecttelephone, or by mail, you do not need to any other matters properly presented at the meeting.

return your proxy card.

If any other matters are properly presented for consideration at the Annual Meeting, including, among other things, consideration of a motion to adjourn the Annual Meeting to another time or place (including, without limitation, for the purpose of soliciting additional proxies), the persons named in the enclosedyour proxy card and acting thereunder will have discretion to vote on those matters in accordance with their best judgment. We do not currently anticipate that any other matters will be raised at the Annual Meeting.

Revocability

If you are a street name stockholder, you will receive voting instructions from your broker, bank, or other nominee. You must follow the voting instructions provided by your broker, bank or other nominee in order to instruct your broker, bank or other nominee on how to vote your shares. Street name stockholders should generally be able to vote by returning an instruction card, or by telephone or on the Internet. However, the availability of Proxy

telephone and Internet voting will depend on the voting process of your broker, bank or other nominee. If you are a street name stockholder, you may not vote your shares on your own behalf at the Annual Meeting unless you obtain a legal proxy from your broker, bank, or other nominee.

How do I revoke my proxy?
You may revoke your proxy by (1) following the instructions on the Notice and entering a new vote by mail overthat we receive before the Internet or by telephone beforestart of the Annual Meeting or over the Internet by the cutoff time of 11:59 p.m. Eastern Time on June 1, 2021, (2) attending and voting at the Annual Meeting and voting in person (although attendance at the Annual Meeting will not in and of itself revoke a proxy)., or (3) by filing an instrument in writing revoking the proxy or another duly executed proxy bearing a later date with our Corporate Secretary. Any written notice of revocation or subsequent proxy card must be received by our Corporate Secretary prior to the taking of the vote at the Annual Meeting. Such written notice of revocation or subsequent proxy card should be hand delivered to our Corporate Secretary or sent to our principal executive offices at ProteostasisYumanity Therapeutics, Inc., 8040 Guest Street, Suite 500,4410, Boston, Massachusetts 02135, Attention: Corporate Secretary.

If a broker, bank, or other nominee holds your shares, you must contact such broker, bank, or nominee in order to find out how to change your vote.

How manyis a quorum reached?
Our Third Amended and Restated Bylaws, or bylaws, provide that a majority of the shares entitled to vote, present in person or represented by proxy, will constitute a quorum for the transaction of business at the Annual Meeting.
Under the General Corporation Law of the State of Delaware, shares that are voted “abstain” or “withheld” and broker “non-votes” are counted as present for purposes of determining whether a quorum is present at the Annual Meeting. If a quorum is not present, the meeting may be adjourned until a quorum is obtained.
How is the vote counted?
Under our bylaws, any proposal other than an election of directors is decided by a majority of the votes properly cast for and against such proposal, except where a larger vote is required by law or by our Fifth Amended and Restated Certificate of Incorporation, or certificate of incorporation, or bylaws. Abstentions and broker “non-votes” are needed to approve each proposal?

The following table summarizesnot included in the minimum vote needed to approve eachtabulation of the voting results on any such proposal and, therefore, do not have an impact on such proposals. A broker “non-vote” occurs when a nominee holding shares for a beneficial owner does not vote on a particular proposal because the nominee does not have discretionary voting power with respect to that item, and has not received instructions from the beneficial owner.

If your shares are held in “street name” by a brokerage firm, your brokerage firm is required to vote your shares according to your instructions. If you do not give instructions to your brokerage firm, the brokerage firm will still be able to vote your shares with respect to certain “discretionary” items, but will not be allowed to vote your shares with respect to “non-discretionary” items. Proposal No. 1 is a “non-discretionary” item. If you do not instruct your broker how to vote with respect to Proposal No. 1, your broker may not vote for Proposal No. 1, and those votes will be counted as broker “non-votes.” Proposal No. 2 is considered to be a discretionary item, and your brokerage firm will be able to vote on this proposal even if it does not receive instructions from you.
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To be elected, the directors nominated via Proposal No. 1 must receive a plurality of the votes cast and entitled to vote on the proposal, meaning that the director nominees receiving the most votes will be elected. Shares voting “withheld” have no effect on the outcome of abstentionsProposal No. 1.
The ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the fiscal year ended December 31, 2021 via Proposal No. 2 requires the affirmative vote of a majority of shares of common stock properly cast andbroker non-votes.

Proposal

No.

Proposal Description

Vote Required for Approval

Effect of
Abstentions

Effect of
Broker
Non-
Votes

1

Election of directorsDirectors will be elected by a plurality of the votes cast at the Annual Meeting by the holders of shares present in person or represented by proxy and entitled to vote on the election of directors. The three nominees receiving the most “FOR” votes will be elected as directors; withheld votes will have no effectNo effectNo effect

2

Ratification of the
appointment of
PricewaterhouseCoopers
LLP as our independent
registered public
accounting firm for the
fiscal year ending
December 31, 2020		“FOR” votes from the holders of a majority of the votes cast for the proposalNo effectNo effect (1)

(1)

This proposal is considered to be a “routine” matter under NYSE rules. Accordingly, if you hold your shares in street name and do not provide voting instructions to your broker, bank or other agent that holds your shares, your broker, bank or other agent has discretionary authority under NYSE rules to vote your shares on this proposal.

Expenses entitled to vote on these proposals. Shares voting “abstain” have no effect on the outcome of Solicitation

Proposal No. 2.

Who pays the cost for soliciting proxies?
We are making this solicitation and will pay the entire cost of preparing and distributing the Notice and theseour proxy materials and soliciting votes. If you choose to access the proxy materials or vote over the Internet, or by telephone, you are responsible for any Internet access charges that you may incur. Our officers and employees may, without compensation other than their regular compensation, solicit proxies through further mailings, personal conversations, facsimile transmissions,e-mails, or otherwise. We have hired Broadridge Financial Solutions, Inc. to assist us in the distribution of proxy materials and the solicitation of votes described above. Proxy solicitation expenses that we will pay

include those for preparation, mailing, returning, and tabulating the proxies. Directors

How may stockholders submit matters for consideration at an annual meeting?
The required notice must be in writing and employees willreceived by our corporate secretary at our principal executive offices not less than 90 days nor more than 120 days prior to the first anniversary of the preceding year’s annual meeting. However, in the event that the date of the annual meeting is advanced by more than 30 days, or delayed by more than 60 days, from the first anniversary of the preceding year’s annual meeting, or if no annual meeting were held in the preceding year, a stockholder’s notice must be paidso received no earlier than the 120th day prior to such annual meeting and not later than the close of business on the later of (A) the 90th day prior to such annual meeting and (B) the tenth day following the day on which notice of the date of such annual meeting was mailed or public disclosure of the date of such annual meeting was made, whichever first occurs.
In addition, any additional compensation for soliciting proxies. We may also reimburse brokerage firms, banks and other agents for the cost of forwarding proxy materials to beneficial owners.

Procedure for Submitting Stockholder Proposals and Director Nominations due for Next Year’s Annual Meeting

Any stockholder proposal intended to be included in the proxy statement for the 2021next annual meeting of our stockholders in 2021 must also satisfy all of the applicable requirements of SEC Rule14a-8 promulgated under the Securities Exchange Act of 1934, as amended, (the “Exchange Act”),or the Exchange Act, and be received not later than March 1,December 23, 2021. If the date of the annual meeting is moved by more than 30 days from the date contemplated at the time of the previous year’s proxy statement, then notice must be received within a reasonable time before we begin to print and send proxy materials. If that happens, we will publicly announce the deadline for submitting a proposal in a press release or in a document filed with the SEC.

Any stockholder proposals intended

How can I know the voting results?
We plan to announce preliminary voting results at the Annual Meeting and will publish final results in a Current Report on Form 8-K to be presented atfiled with the next annual meeting of our stockholders other than those to be included in our proxy materialsSEC within four business days following the procedures described in Rule14a-8 must satisfy the requirements set forth in the advance notice provision under ourBy-laws. To be timely for our 2021 annual meeting, any such proposal must be delivered in writing to our Secretary at our principal executive offices no earlier than the close of business on March 1, 2021 (120 days prior to the first anniversary of our 2020 Annual Meeting) and no later than the close of business on March 31, 2021 (90 days prior to the first anniversary of our 2020 Annual Meeting). If the date of the 2021 annual meeting is scheduled to take place before May 30, 2021 (30 days prior to the first anniversary of our 2020 Annual Meeting) or after August 28, 2021 (60 days after the first anniversary of our 2020 Annual Meeting), notice by the stockholder must be delivered no later than the close of business on the later of (1) the 90th day prior to the 2021 annual meeting or (2) the 10th day following the day on which public announcement of the date of the 2021 annual meeting is first made.Meeting.
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OVERVIEW OF PROPOSALS

This Proxy Statement contains two proposals requiring stockholder action. Proposal 1 requests the election of three directors to the Board of Directors. Proposal 2 requests the ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2020.2021. Each of the proposals is discussed in more detail in the pages that follow.

PROPOSAL 1

ELECTION OF DIRECTORS

Our Board of Directors is divided into three classes. One class is elected each year at the annual meeting of stockholders for a term of three years. Vacancies on the Board of Directors are filled exclusively by the affirmative vote of a majority of the remaining directors, even if less than a quorum is present, and not by stockholders. A director elected by the Board of Directors to fill a vacancy in a class shall hold office for the remainder of the full term of that class, and until the director’s successor is duly elected and qualified or until his or her earlier resignation, death, or removal.

The Board of Directors presently has sevennine members. There are three Class IIIII directors whose terms of office expire on the date of the upcoming Annual Meeting. Based on the recommendation of the Nominating and Corporate Governance Committee of the Board of Directors, the Board of Directors’ nominees for election by the stockholders are the current Class IIIII members: Meenu Chhabra, Jeffery W. Kelly,N. Anthony Coles, M.D., Kim C. Drapkin and Lynne Zydowsky, Ph.D. and David Arkowitz. If elected, each nominee will serve as director until our 20232024 annual meeting of Stockholders (the “2023“2024 Annual Meeting”) and until his or her successor is duly elected and qualified, or, if sooner, until his or her earlier death, resignation, or removal.

The names of and certain information about the directors in each of the three classes are set forth below. There are no family relationships among any of our directors or executive officers.

It is intended that the proxy in the form presented will be voted, unless otherwise indicated, for the election of the Class IIIII director nominees to the Board of Directors. If a nominee should for any reason be unable or unwilling to serve at any time prior to the Annual Meeting, the proxies will be voted for the election of such substitute nominee as the Board of Directors may designate. Each nominee has agreed to serve if elected. Our management has no reason to believe that any nominee will be unable to serve.

Director Nominees and Continuing Directors

The following is a brief biography of each nominee for director and each director whose term of office will continue after the Annual Meeting, and a discussion of the specific experience, qualifications, attributes or skills of each nominee that led the Nominating and Corporate Governance Committee to recommend that person as a nominee for director, as of the date of this Proxy Statement.

Nominees for Election as a Class IIIII Director for a Three-Year Term Expiring at the 20232024 Annual Meeting

Name

  

Positions and Offices Held

  Director Since  Age

Meenu Chhabra

  President, Chief Executive Officer and Director  2014  47

Jeffery W. Kelly, Ph.D.

  Director  2006  59

David Arkowitz

  Director  2019  58

Meenu Chhabra. Ms. Chhabra

Name
​​
Positions and Offices Held
​​
Director Since(1)
​​
Age
N. Anthony Coles, M.D.
​​
Executive Chair of the Board of Directors
​​
2014
​​
60
Kim C. Drapkin
​​
Director
​​
2020(2)
​​
53
Lynne Zydowsky, Ph.D.
​​
Director
​​
2019
​​
62
(1)
The years set forth below reflect when the director joined Yumanity, Inc. (formerly Yumanity Therapeutics, Inc.).
(2)
Ms. Drapkin joined Yumanity at the completion of the merger of Proteostasis Therapeutics, Inc. (“Proteostasis”) and Yumanity, Inc. in December 2020.
N. Anthony Coles, M.D. has served as our President and Chief Executive Officer and a member of our Board of Directors since May 2014. In January 2020, she also becamethe completion of the merger of Proteostasis and Yumanity, Inc. in December 2020. He co-founded Yumanity, Inc. and previously served as Yumanity, Inc.’s Executive Chair of the board of directors since September 2019 and as a member of Yumanity, Inc.’s board of directors since December 2014. Dr. Coles previously served as Yumanity, Inc.’s President and Chief Executive Officer from October 2014 to September 2019. Dr. Coles has served as the Emerging Companies Section withinChairperson of the board of directors of Cerevel Therapeutics since December 2018 and has been the Biotechnology Industry Organization. Ms. Chhabra alsoPresident and Chief Executive Officer of Cerevel Therapeutics since September 2019. Previously, Dr. Coles served as President, Chief Executive Officer and
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Chairperson of the board of Onyx Pharmaceuticals, Inc., from 2012 until its sale to Amgen in 2013, having served as its President, Chief Executive Officer and a member of its board of directors from 2008 until 2012. Prior to joining Onyx Pharmaceuticals, Inc., Dr. Coles was President, Chief Executive Officer and a director of NPS Pharmaceuticals, Inc. Before joining NPS Pharmaceuticals, Inc. in 2005, Dr. Coles was Senior Vice President of Commercial Operations at Vertex Pharmaceuticals Inc., and earlier, held several executive positions at Bristol-Myers Squibb Company and positions of increasing responsibility at Merck & Co., Inc. In addition to having previously served as a director of Onyx Pharmaceuticals and NPS Pharmaceuticals, Dr. Coles was formerly a director of CRISPR Therapeutics AG, Laboratory Corporation of America Holdings and Campus Crest Communities, Inc. Dr. Coles currently serves on the board of directors of Vasomune Therapeutics,Regeneron Pharmaceuticals, Inc., Dr. Coles also currently serves on the board of directors of McKesson Corporation but will not stand for re-election at its next annual shareholders meeting in July 2021. Dr. Coles earned a privately held biopharmaceutical company. From August 2007 to May 2014, Ms. Chhabra was President and Chief Executive OfficerB.A. at Allozyne, Inc.,Johns Hopkins University, a biopharmaceutical company. From December 2006 to August 2007, she served as Vice President of Business Development and Licensing at the Novartis Pharmaceuticals division of Novartis AG. From July 2003 to November 2006, she served as Chief Business Officer at BioXell SpA, aspin-offM.D. from F. Hoffmann-LaRoche Ltd.’s Milan Research Institute (Italy), where she led corporate development and financing activities. Ms. Chhabra has also held management positions with Fresenius Kabi AG, Warner-Lambert Company, LLC, and Bristol-Myers Squibb

Company. She obtained her M.B.A. from YorkDuke University, and her B.Sc.a M.P.H. from the University of Toronto.Harvard University. He completed his cardiology and internal medicine training at Massachusetts General Hospital and was a research fellow at Harvard Medical School. We believe that Ms. Chhabra’s deep knowledgeDr. Coles is qualified to serve on our Board of Directors because of his extensive leadership, executive, managerial and operationalstrategic business experience gained from serving as our President and Chief Executive Officer, combined with her extensive experience in the biopharmaceutical industry qualify her to servelife sciences companies.

Kim C. Drapkin, CPA, has served as a member of our Board of Directors.

Jeffery W. Kelly, Ph.D. Dr. Kelly, aco-founder of our company, has served on our Board of Directors since the completion of the merger of Proteostasis and Yumanity, Inc. in December 2006, when our company was founded. Since January 2019, he has2020 and previously served on the board of directors and as a scientist of The Scripps Research Institute in La Jolla, California. From September 2008 until 2019, he served as the Chairman of Molecular and Experimental Medicine and the Lita Annenberg Hazen Professor of Chemistry within the Skaggs Institute of Chemical Biology at The Scripps Research Institute. From August 2000 to December 2008, he served as Dean of Graduate Studies at The Scripps Research Institute, and from July 2000 to December 2006, he also served as Vice President of Academic Affairs. Dr. Kelly alsoco-founded two other companies, FoldRx Pharmaceuticals, Inc. and Misfolding Diagnostics Inc. He received his Ph.D. in organic chemistry from the University of North Carolina at Chapel Hill. We believe that Dr. Kelly’s long history with our company and scientific and technical expertise qualify him to serve as a member of our Board of Directors.

David Arkowitz. Mr. Arkowitz has served as the Chief Financial Officer of Flexion Therapeutics, Inc. since May 2018. From September 2013 to May 2018, Mr. Arkowitz served as Chief Operating Officer and Chief Financial Officer at Visterra (acquired by Otsuka Pharmaceutical Co.), where he led the finance, business development, corporate planning and other functions. Mr. Arkowitz was Chief Financial Officer and General Manager at Mascoma Corporation from June 2011 to September 2013. Previously, Mr. Arkowitz served as Chief Financial Officer and Chief Business Officer at AMAG Pharmaceuticals, and Chief Financial Officer of Idenix Pharmaceuticals (acquired by Merck & Co., Inc.). Prior to Idenix, Mr. Arkowitz spent more than 13 years at Merck & Co., Inc. where he held roles of increasing responsibility, including Vice President and Controller of the U.S. Human Health division and Controller of the Global Research and Development division, and Chief Financial Officer of the Canadian subsidiary. Mr. Arkowitz serves on the board of directors of Spring Bank Pharmaceuticals. Mr. Arkowitz earned a B.A. in Mathematics from Brandeis University and an M.B.A. in Finance from Columbia University Business School. We believe that Mr. Arkowitz’s extensive financial and operational life sciences experience qualify him to serve as a member of our Board of Directors.

Continuing Directors

Name

  

Positions and Offices Held

  Director
Since		  

Class and Year
in Which Term
Will Expire

  Age

Franklin M. Berger, CFA

  Chairman of the Board of Directors  2016  Class I—2022  70

Badrul A. Chowdhury, M.D., Ph.D.

  Director  2019  Class I—2022  62

Kim C. Drapkin, CPA

  Director  2019  Class III—2021  52

Emmanuel Dulac, PharmD, Ph.D.

  Director  2019  Class III—2021  50

Franklin M. Berger, CFA. Mr. Berger has served on our Board of DirectorsProteostasis since February 2016 and as Chairman since June 2019. Mr. Berger is a consultant to biotechnology industry participants, including major biopharmaceutical firms,mid-capitalization biotechnology companies, specialist asset managers and venture capital companies, providing business development, strategic advisory, financing, partnering and royalty acquisition advice. Mr. Berger is also a biotechnology industry analyst with over 25 years of experience in capital markets and financial analysis. Mr. Berger worked at Sectoral Asset Management as aco-founder of thesmall-cap focused NEMO Fund from January 2007 through May 2008. From May 1998 to March 2003, he served at J.P. Morgan Securities, most recently as Managing Director, Equity Research and Senior Biotechnology Analyst. Previously, Mr. Berger served in similar capacities at Salomon Smith Barney and Josephthal & Co. Mr. Berger also serves on the boards of directors of BELLUS Health, Inc., Five Prime Therapeutics, Inc., ESSA Pharma, Inc., Tocagen Inc., Atreca Inc, Kezar Life Sciences, Inc. and CERUS Endovascular Ltd. Mr. Berger formerly served on the boards of directors of Aurinia Pharmaceuticals, Inc.,

Immune Design Corp., Seattle Genetics, Inc., Emisphere Technologies, Inc., BioTime, Inc. and VaxGen, Inc., each of whom were public biopharmaceutical companies during Mr. Berger’s service as a director. Mr. Berger received a B.A. in International Relations and an M.A. in International Economics both from Johns Hopkins University and an M.B.A. from the Harvard Business School. He is also a Chartered Financial Analyst. We believe that Mr. Berger’s financial background and experience as an equity analyst in the biotechnology industry combined with his extensive experience serving on the boards of directors of multiple public companies are important to our strategic planning and financing activities and qualify him to serve as a member of our Board of Directors.

Badrul A. Chowdhury, M.D., Ph.D. Dr. Chowdhury has served as the Chief Medical Officer of Savara Inc. since November 2019. Prior to joining Savara, he served as Senior Vice President, Chief Physician-Scientist, Respiratory Inflammation and Autoimmunity, Late Stage, Research and Development Biopharmaceuticals, AstraZeneca and Senior Vice President, Research and Development, Astra Zeneca Medimmune; Head of Respiratory Inflammation and Autoimmunity (RIA) Innovative Medicine Early Development at Medimmune from April 2019 to November 2019. Prior to joining AstraZeneca, Dr. Chowdhury served at the United States Food and Drug Administration (FDA) where he held numerous leadership roles, including Director of the Division of Pulmonary, Allergy, and Rheumatology Products at the FDA’s Center for Drug Evaluation and Research (CDER). Dr. Chowdhury has a M.B., B.S. in Medicine from University of Dhaka, Dhaka Medical College, Bangladesh, and a Ph.D. in Immunology from Memorial University of Newfoundland, Canada. He completed his residency training in Internal Medicine at the Wayne State University School of Medicine, Detroit, Michigan, and fellowship in Allergy and Immunology at the National Institutes of Health’s, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, and is double board certified in Internal Medicine and Allergy and Immunology. We believe that Dr. Chowdhury’s extensive clinical trial and regulatory strategy expertise at the FDA and with the pharmaceutical industry qualify him to serve as a member of our Board of Directors.

Kim C. Drapkin, CPA. Ms. Drapkin has served as the Chief Financial Officer of Jounce Therapeutics, Inc. since August 2015 and as its Treasurer since February 2013. From 2009 to August 2015, Ms. Drapkin was the owner of KCD Financial LLC, a consulting firm, through which she served as Jounce Therapeutics’ interim Chief Financial Officer from 2012 to August 2015 and consulted for numerous biotechnology companies. Previously, Ms. Drapkin served as Chief Financial Officer of Predix Pharmaceuticals Holdings, Inc. from 2005 to 2006, and, after Predix was acquired by EPIX Pharmaceuticals, Inc., as the Chief Financial Officer of EPIX from 2006 to 2009. From 1995 to 2005, Ms. Drapkin served in a variety of roles of increasing responsibility at Millennium Pharmaceuticals, Inc., (acquired by Takeda Pharmaceutical Company), including Director of Finance. Ms. Drapkin began her career at PricewaterhouseCoopers LLP, is a certified public accountant and holds a B.S. in accounting from Babson College. We believe that Ms. Drapkin’sDrapkin is qualified to serve on our Board of Directors because of her extensive financial expertise within the pharmaceutical industry qualify her to serveindustry.

Lynne Zydowsky, Ph.D. has served as a member of our Board of Directors.

Emmanuel Dulac, PharmD, Ph.D.Directors since the completion of the merger of Proteostasis and Yumanity, Inc. in December 2020 and previously served as a member of the board of directors of Yumanity, Inc. since October 2019. Dr. DulacZydowsky has served as the President and co-founder of the Alexandria Summit since 2011, the Chief ExecutiveScience Officer of Alexandria Real Estate Equities, Inc./Alexandria Venture Investments since 2016 and President of Zealand Pharma A/SZydowsky Consultants, a consulting practice offering services to life sciences company, since April 2019.August 2003. Prior to Zealand Pharma A/S,that, Dr. DulacZydowsky was Chief Commercial Officerco-founder and Chief International Strategy at Alnylam Pharmaceuticals from August 2016 to April 2019,Operating officer of Renovis, Inc. (now Evotec) and Seniorserved as Vice President Global Head Rare Diseaseof Pharmaceutical Business Unit, General ManagerDevelopment at Exelixis, Inc. Dr. Zydowsky has served on the board for the Reagan-Udall Foundation for the FDA since October 2018, the Board of United States OperationsTrustees for Butler University since September 2016, and the Discovery Council for Harvard Medical School since August 2018. She serves as a Board Observer for OneFifteen, a non-profit healthcare ecosystem dedicated to the full and sustained recovery of people living with opioid addiction, on behalf of Alexandria Real Estate Equities, Inc. She serves on the West Coast Board of buildOn, an international non-profit focused on breaking the cycle of poverty, illiteracy, and low expectations through its youth programs. Dr. Zydowsky earned her Ph.D. in chemistry from The Ohio State University and was a National Institutes of Health postdoctoral fellow in the Department of Biological Chemistry and Molecular Pharmacology at Shire, plc (acquired by Takeda Pharmaceutical Company)Harvard Medical School. She has a B.S. in pharmacy from June 2014 to August 2016. Dr. Dulac held several leadership roles of increasing responsibility at Novartis from February 2006 to May 2014, including Vice President, Global Head Lung/Cystic Fibrosis. From August 2003 to February 2006, he served as Business Unit Lead for Cardiovascular Medicine at Abbott. Dr. Dulac held several roles of increasing responsibility at Sanofi from October 1994 to August 2003, including Associate Director. Dr. Dulac earned a Doctorate in Pharmacology (PharmD, Ph.D.) from the University of Paris XI and IV and an M.B.A. from the ESSEC Business School in Paris.Butler University. We believe that Dr. Dulac’s clinical development and commercial expertise, particularly in cystic fibrosis, qualify himZydowsky is qualified to serve on our Board of Directors because of her experience working with life sciences companies and knowledge of the life sciences industry.

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Continuing Directors
Name
​​
Positions and Offices Held
​​
Director
Since(1)
​​
Class and Year
in Which Term
Will Expire
​​
Age
Patricia L. Allen
​​
Director
​​
2019
​​
Class I—2022
​​
59
Richard A. Heyman, Ph.D.
​​
Lead Independent Director
​​
2016
​​
Class I—2022
​​
63
Richard Peters, M.D., Ph.D.
​​
President, Chief Executive Officer and Director
​​
2019
​​
Class I—2022
​​
58
David Arkowitz
​​
Director
​​
2020(2)
​​
Class II—2023
​​
59
Jeffery W. Kelly, Ph.D.
​​
Director
​​
2006
​​
Class II—2023
​​
60
Cecil B. Pickett
​​
Director
​​
2016
​​
Class II—2023
​​
76
(1)
The years set forth below reflect when the director joined Yumanity, Inc. (formerly Yumanity Therapeutics, Inc.).
(2)
Mr. Arkowitz joined Yumanity at the completion of the merger of Proteostasis and Yumanity, Inc. in December 2020.
Patricia L. Allen has served as a member of our Board of Directors.Directors since the completion of the merger of Proteostasis and Yumanity, Inc. in December 2020 and previously served as a member of the board of directors of Yumanity, Inc. since August 2019. Ms. Allen is currently the Chief Financial Officer of Vividion Therapeutics, Inc. since March 2021. From January 2013 to May 2020, Ms. Allen served as the Chief Financial Officer of Zafgen, Inc., which was acquired by Larimar Therapeutics, Inc. Ms. Allen has over 25 years of financial leadership experience in the biotechnology industry at both publicly traded and private companies. From 2011 to 2012, she provided independent consulting services to biotechnology companies in a variety of areas, including interim chief financial officer services, fundraising, deal structures, financial planning, organizational structure, investor relations and business development. Previously, from 2004 to 2011, Ms. Allen served as the Vice President of Finance, Treasurer and Principal Financial Officer of Alnylam Pharmaceuticals, Inc. Ms. Allen began her career as an auditor at Deloitte & Touche, LLP. Ms. Allen also serves on the board of directors and the chair of the audit committee of Deciphera Pharmaceuticals, Inc., a publicly-traded company, since 2016. Ms. Allen graduated summa cum laude from Bryant College with a B.S. in business administration. We believe Ms. Allen is qualified to serve on our Board of Directors because of her financial expertise and her experience as an executive of companies in the life sciences industry.
Richard A. Heyman, Ph.D. has served as a member of our Board of Directors since the completion of the merger of Proteostasis and Yumanity, Inc. in December 2020 and previously served as a member of the board of directors of Yumanity, Inc. since May 2016. Dr. Heyman is the co-founder of Metacrine, Inc. and has served as the Chairman of its board of directors since June 2015. He also serves as a member of the boards of directors of Gritstone Oncology, Inc., ORIC Pharmaceuticals, Inc. and BCTG Acquisition Corp. Dr. Heyman was a co-founder of ORIC Pharmaceuticals, Inc. and served as its Interim Chief Executive Officer from October 2015 to June 2016. From August 2013 to April 2015, Dr. Heyman served as the Chief Executive Officer of Seragon Pharmaceuticals, Inc., a private biotechnology company which was acquired by Genentech in August 2014. Prior to joining Seragon, Dr. Heyman co-founded and served as the Chief Executive Officer of Aragon Pharmaceuticals, Inc. until it was acquired by Johnson & Johnson in August 2013. Dr. Heyman also serves on the boards of directors for private life sciences companies Vividion Therapeutics, Inc., PMV Pharmaceuticals, Inc. and Amunix Inc. He is a member of the Board of Trustees at the Salk Institute and on the Board of Visitors at the University of California at San Diego Moores Cancer Center. Dr. Heyman received a Ph.D. in pharmacology from the University of Minnesota and a B.S. in chemistry from the University of Connecticut. We believe Dr. Heyman is qualified to serve on our Board of Directors because of his experience as an executive of companies in the life sciences industry.
Richard Peters, M.D., Ph.D. has served as our President, Chief Executive Officer and member of our Board of Directors since the completion of the merger of Proteostasis and Yumanity, Inc. in December 2020 and has served as the President, Chief Executive Officer and a member of the board of directors of Yumanity, Inc. since September 2019. Dr. Peters previously served as the President and Chief Executive Officer and a member of the board of directors of Merrimack Pharmaceuticals, a biopharmaceutical company, from February 2017 to June 2019. Previously, Dr. Peters served in various capacities at Sanofi Genzyme, a global pharmaceutical company, since 2008, including as Senior Vice President, Head of Global Rare Diseases Business Unit since January 2015, Vice President, Strategy Development Officer, U.S. Rare Disease Unit from May 2014 to December 2014, Vice President, Division Medical Officer, Global Oncology Division from 2011 to May 2014, and Vice President, Head of Global and U.S. Medical Affairs, Hematology and Transplant from 2008 to 2011. Prior to Sanofi Genzyme, Dr. Peters held
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medical affairs roles at Onyx Pharmaceuticals, Inc. and Amgen Inc., both pharmaceutical companies, and was a co-founder and Chief Executive Officer of Mednav, Inc., a private healthcare information technology company. Dr. Peters has served on the board of directors of Aprea Therapeutics, Inc., a biopharmaceutical company since June 2020 and as chair of the compensation committee since September 2020. Dr. Peters has been an active founder, angel investor, and Board member of several biotechnology start-ups. Dr. Peters has also served on the faculty at Harvard Medical School/Massachusetts General Hospital. Dr. Peters holds an M.D. and a Ph.D. in pharmacology from the Medical University of South Carolina and a B.S. from the College of Charleston. We believe Dr. Peters is qualified to serve on our Board of Directors because of his extensive industry knowledge and experience in research and development.
David Arkowitz has served as a member of our Board of Directors since the completion of the merger of Proteostasis and Yumanity, Inc. in December 2020 and previously served on the board of directors of Proteostasis since March 2019. Mr. Arkowitz has served as the Chief Financial Officer of Flexion Therapeutics, Inc. since May 2018. From September 2013 to May 2018, Mr. Arkowitz served as Chief Operating Officer and Chief Financial Officer at Visterra (acquired by Otsuka Pharmaceutical Co.), where he led the finance, business development, corporate planning and other functions. Mr. Arkowitz was Chief Financial Officer and General Manager at Mascoma Corporation (acquired by Lallemand Inc.) from June 2011 to September 2013. Previously, Mr. Arkowitz served as Chief Financial Officer and Chief Business Officer at AMAG Pharmaceuticals, and Chief Financial Officer of Idenix Pharmaceuticals (acquired by Merck & Co., Inc.). Prior to Idenix, Mr. Arkowitz spent more than 13 years at Merck & Co., Inc. where he held roles of increasing responsibility, including Vice President and Controller of the U.S. Human Health division and Controller of the Global Research and Development division, and Chief Financial Officer of the Canadian subsidiary. Mr. Arkowitz serves on the board of directors of F-Star Therapeutics, Inc., where he also serves as the chair of the audit committee and a member of the compensation committee. Mr. Arkowitz earned a B.A. in Mathematics from Brandeis University and an M.B.A. in Finance from Columbia University Business School. We believe Mr. Arkowitz is qualified to serve on our Board of Directors because of his extensive financial and operational life sciences experience.
Jeffery W. Kelly, Ph.D. has served as a member of our Board of Directors since the completion of the merger of Proteostasis and Yumanity, Inc. in December 2020 and previously served as a member of the board of directors of Yumanity, Inc. since December 2014 and as a member of the board of directors of Proteostasis since co-founding the company in December 2006. Dr. Kelly is the Lita Annenberg Hazen Professor of Chemistry within the Skaggs Institute of Chemical Biology at The Scripps Research Institute since 1997. Since late 2018, Dr. Kelly has served as the faculty representative on the board of directors of The Scripps Research Institute. Prior to that he served as Chairman of the Departments of Chemistry (2018) and Molecular and Experimental Medicine (2008 – 2017), Dean of Graduate Studies (2000 – 2008), and Vice President of Academic Affairs (2000 – 2006) at The Scripps Research Institute. Dr. Kelly also co-founded FoldRx Pharmaceuticals, Inc., and Protego Biopharma, Inc. He received his Ph.D. in organic chemistry from the University of North Carolina at Chapel Hill and received postdoctoral training at the Rockefeller University. At his lab at Scripps, Professor Kelly discovered tafamidis, a drug developed by FoldRx and acquired by Pfizer. We believe he is qualified to serve on our Board of Directors because of his long history with Proteostasis and Yumanity and his scientific and technical expertise in neurodegenerative diseases.
Cecil B. Pickett, Ph.D. has served as a member of our Board of Directors since the completion of the merger of Proteostasis and Yumanity, Inc. in December 2020 and previously served as a member of the board of directors of Yumanity, Inc. since May 2016. Dr. Pickett served as President, Research and Development and a member of the board of directors of Biogen Idec Inc. from September 2006 until his retirement in October 2009. Prior to joining Biogen Idec, Dr. Pickett held several senior R&D positions, including Corporate Senior Vice President of Schering-Plough Corp. and President of Schering-Plough Research Institute. Prior to joining Schering-Plough, he held several senior R&D positions at Merck & Co. Dr. Pickett received a B.S. in biology from California State University at Hayward and a Ph.D. in cell biology from University of California at Los Angeles. He is a member of the National Academy of Medicine and previously served as a director of Zimmer Biomet from March 2008 to March 2018. We believe Dr. Pickett is qualified to serve on our Board of Directors because of his scientific background and experience in the life sciences industry.
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Vote Required

Directors will be elected by a plurality of the votes cast by the stockholders entitled to vote on this proposal at the Annual Meeting. Accordingly, if a quorum is present, the three nominees receiving the highest number of affirmative votes will be elected as Class IIIII directors. Brokernon-votes and proxies marked to withhold authority with respect to the Class IIIII directors will not be treated as votes cast for this purpose and, therefore, will not affect the outcome of the election.

Shares represented by executed proxies will be voted, if authority to do so is not withheld, for the election of the nominees named herein. Proxies cannot be voted for a greater number of persons than the three nominees named in this Proxy Statement.

The Board of Directors recommends that stockholders vote “FOR”

the election of each named Class IIIII director nominee listed above.

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PROPOSAL 2



RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED
PUBLIC ACCOUNTING FIRM

On

Yumanity’s stockholders are being asked to ratify the recommendation ofappointment by the Audit Committee of the Board of Directors has appointedof PricewaterhouseCoopers LLP as ourthe Company’s independent registered public accounting firm for the fiscal year ending December 31, 2020. 2021. PricewaterhouseCoopers LLP had served as Proteostasis’ independent registered public accounting firm since 2014 and had audited Yumanity, Inc.’s financial statements since 2018.
The Board of Directors recommends that stockholders voteAudit Committee is solely responsible for ratification of this appointment. If this proposalselecting Yumanity’s independent registered public accounting firm for the fiscal year ending December 31, 2021. Stockholder approval is not approved at the Annual Meeting,required to appoint PricewaterhouseCoopers LLP as Yumanity’s independent registered public accounting firm. However, the Board of Directors believes that submitting the appointment of PricewaterhouseCoopers LLP to the stockholders for ratification is good corporate governance. If the stockholders do not ratify this appointment, the Audit Committee will reconsider its appointment. Even ifwhether to retain PricewaterhouseCoopers LLP. If the appointmentselection of PricewaterhouseCoopers LLP is ratified, the Audit Committee, may, inat its discretion, may direct the appointment of a different independent registered public accounting firm at any time during the year if the Audit Committee determinesit decides that such a change would be in our stockholders’the best interests.

PricewaterhouseCoopers LLP has audited our financial statements since 2014. We expect representativesinterest of Yumanity and its stockholders.

A representative of PricewaterhouseCoopers LLP is expected to be present at the virtual Annual Meeting and available to respond to appropriate questions. They will have thean opportunity to make a statement if they desirehe or she desires to do so.

so and to respond to appropriate questions from our stockholders.

The following table sets forth all fees paid or accrued by us for professional audit services and other services rendered by PricewaterhouseCoopers LLP during the years ended December 31, 2019 and December 31, 2020.
Independent Registered Public Accounting Firm Fees and Services

The following table sets forth the aggregate fees billed for professional audit services and other services rendered to us by PricewaterhouseCoopers LLP, an independent registered public accounting firm, to Yumanity for the fiscal yearsyear ended December 31, 20192020 and 2018.

   Fiscal 2019   Fiscal 2018 

Audit Fees

  $783,000   $1,003,000 

All Other Fees

   2,756    2,756 
  

 

 

   

 

 

 

Total

  $785,756   $1,005,756 
  

 

 

   

 

 

 

Audit Fees.Audit fees consist of fees billed for professional services performed by PricewaterhouseCoopers LLPto Proteostasis for the audit of our annual financial statements, the review of interim financial statements, and related services that are normally provided in connection with registration statements, including the registration statement for ourfollow-on public offering and ourat-the-market offering program. Included in the 2019 Audit Fees is $130,000 of fees billed in connection with ourat-the-market offering program and included in the 2018 Audit Fees is $320,000 of fees billed in connection with ourat-the-market offering program and ourfollow-on offering that closed in October 2018.

All Other Fees. All other fees consist of licenses for PricewaterhouseCoopers LLP’s online accounting research tool and quarterly periodic disclosure checklists.

fiscal year ended December 31, 2019.

 
​​
2020
​​
2019
Audit fees(1)
​​
$1,600,000
​​
$783,000
Audit-related fees(2)
​​
—
​​
—
Tax-related fees(3)
​​
31,155
​​
—
All other fees(4)
​​
956
​​
2,756
Total fees
​​
$​1,632,111
​​
$785,756
(1)
Audit fees. Audit fees consist of fees billed for professional services performed by PricewaterhouseCoopers LLP for the audit of our annual financial statements, the review of interim financial statements, and related services that are normally provided in connection with registration statements. During fiscal year 2020, Yumanity audit fees includes $666,000 of fees in connection with the filing of registration statements.. During fiscal year 2019, Yumanity incurred total audit fees of $65,000, which is not included in the table above.
(2)
Audit-related fees. There were no audit-related fees in fiscal years 2020 and 2019.
(3)
Tax-related fees. Tax-related fees consist of fees billed for the preparation of the annual tax returns and tax-related consulting work. During 2019, Yumanity incurred $35,559 of tax-related fees, which is not included in the table above.
(4)
All other fees. All other fees consist of licenses for PricewaterhouseCoopers LLP’s online accounting research and financial disclosure tools.
All fees described above werepre-approved by the Audit Committee.

Pre-Approval of Audit andNon-Audit Services

Our Board of Directors and Audit Committee have adopted a policy that all services to be provided by our independent registered public accounting firm, including audit services and permitted audit-related andnon-audit services, must be approved in advance by our Audit Committee.

Vote Required

To be approved, Proposal 2 must receive “FOR” votes from the holders of a majority of the votes properly cast vote for this proposal. Shares that are voted “abstain” will have no effect on the outcome of this proposal.

The Board of Directors recommends that stockholders vote “FOR” ratification of the appointment of


PricewaterhouseCoopers LLP as our independent registered public accounting firm.

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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

The following table sets forth certain information regarding beneficial ownership of our common stock as of April 13, 2020,9, 2021, for: each person known to us to be the beneficial owner of more than five percent of our outstanding common stock; each of our named executive officers; each of our directors; and all of our current directors and executive officers as a group.

Beneficial ownership is determined in accordance with the rules of the SEC and generally includes voting or investment power with respect to securities. Except as noted by a footnote, and subject to community property laws where applicable, we believe based on the information provided to us that the persons and entities named in the table below have sole voting and investment power with respect to all shares of our common stock shown as beneficially owned by them.

The table lists applicable percentage ownership based on 52,147,65610,193,831 shares of our common stock outstanding as of April 13, 2020.9, 2021. The number of shares beneficially owned includes shares of our common stock that each person has the right to acquire within 60 days of April 13, 2020,9, 2021, including upon the exercise of stock options. These stock options shall be deemed to be outstanding for the purpose of computing the percentage of outstanding shares of our common stock owned by such person but shall not be deemed to be outstanding for the purpose of computing the percentage of outstanding shares of our common stock owned by any other person.

This table is based upon information supplied by our officers, directors and principal stockholders and Schedules 13D and 13G filed with the SEC. Except as otherwise noted below, the address for each executive officer and director listed in the table is c/o ProteostasisYumanity Therapeutics, Inc., 8040 Guest Street, Suite 500,4410, Boston, Massachusetts 02135.

Name and Address of Beneficial Owner

  Number  Percent 

5% Stockholders

   

Entities affiliated with 1Globe Capital LLC(1)

   4,545,308   8.7% 

Entities affiliated with Perrigo Science One Ltd.(2)

   2,908,067   5.6% 

Named Executive Officers and Directors

   

Meenu Chhabra(3)

   1,147,588   2.2% 

Sheila Wilson(4)

   144,072*  

Marija Zecevic, Ph.D.(5)

   209,520*  

Po-Shun Lee, M.D.(6)

   30,670*  

Franklin M. Berger, CFA(7)

   402,360*  

Jeffery W. Kelly, Ph.D.(8)

   252,484*  

David Arkowitz(9)

   12,750*  

Kim C. Drapkin, CPA(9)

   12,750*  

Emmanuel Dulac, PharmD, Ph.D.(9)

   12,750*  

Badrul A. Chowdhury, M.D., Ph.D.(9)

   10,200*  

All current directors and executive officers as a group (11 persons)(10)

   2,610,045   4.8% 

Name and Address of Beneficial Owner
​​
Number
​​
Percent
5% Stockholders
​​
 
​​
 
Entities affiliated with the estate of Susan Lindquist, Ph.D.(1)
​​
1,190,599
​​
11.7%
Entities Associated with Fidelity(2)
​​
1,186,089
​​
11.6%
N. Anthony Coles, M.D.(3)
​​
839,729
​​
8.2%
Entities Associated with Alexandria Real Estate Equities, Inc.(4)
​​
781,034
​​
7.7%
Entities Associated with Redmile Group, LLC(5)
​​
673,549
​​
6.6%
Merck Sharp & Dohme Corp.(6)
​​
526,999
​​
5.2%
Named Executive Officers and Directors
​​
 
​​
 
N. Anthony Coles, M.D.(3)
​​
839,729
​​
8.2%
Richard Peters, M.D., Ph.D(7)
​​
259,207
​​
2.5%
Paulash Mohsen(8)
​​
92,271
​​
*
Meenu Chhabra(9)
​​
84,838
​​
*
Sheila Wilson(10)
​​
18,363
​​
*
Marija Zecevic, Ph.D.(11)
​​
27,109
​​
*
Patricia L. Allen(12)
​​
17,766
​​
*
Richard A. Heyman, Ph.D. (13)
​​
11,429
​​
*
Kim C. Drapkin(14)
​​
2,400
​​
*
David Arkowitz(15)
​​
6,747
​​
*
Jeffery W. Kelly, Ph.D.(16)
​​
24,265
​​
*
Cecil B. Pickett(17)
​​
11,429
​​
*
Lynne Zydowsky, Ph.D.(18)
​​
17,766
​​
*
All current directors and executive officers as a group (12 persons)(19)
​​
1,344,331
​​
12.5%
*

IndicatesRepresents beneficial ownership of less than one percent.

percent
(1)

The information shown is as of December 31, 2019 and is basedBased solely on Amendment No. 2 toa Schedule 13G filed with the SEC by 1Globe Capital LLC (“1Globe”) on February 14, 2020. 1Globe has sole voting and dispositive power over these shares. The address for 1Globe is One International Place, Suite 4420, Boston, Massachusetts 02110.

(2)

The information shown is as of December 31, 2016 and is based solely on the Schedule 13G filed on February 13, 2017 by (i) Perrigo Company plc, (ii) Perrigo Holdings Ltd., (iii) Perrigo Pharma International DAC, (iv) Perrigo Corporation Ltd. and (v) Perrigo Science One Ltd (collectively, the “Perrigo Entities”). The Perrigo Entities have shared voting and dispositive power with respect to 2,908,067 shares. The address for the entities affiliated with Perrigo is. Treasury Building, Lower Grand Canal Street, Dublin 2, Ireland.

(3)

January 4, 2021. Consists of (i) 1,066,973230,170 shares of common stock held by the Susan L. Lindquist Exempt Marital Trust, (ii) 241,257 shares of common stock held by the Susan L. Lindquist Non-Exempt Marital Trust, (iii) 228,966 shares of common stock held by the Susan L. Lindquist Massachusetts Only Marital Trust, (iv) 484,168 shares of common stock held by the Susan L. Lindquist Family Trust and (v) 6,038 shares of common stock issuable upon exercise of warrants within 60 days of April 9, 2021 held by the Susan L. Lindquist Family Trust. The address for each of the Susan L. Lindquist Exempt Marital Trust, Susan L. Lindquist Non-Exempt Marital Trust, Susan L. Lindquist Massachusetts Only Marital Trust and Susan L. Lindquist Family Trust is c/o Nancy E. Dempze, Hemenway & Barnes, LLP 75 State Street, 16th Fl., Boston, Massachusetts 02109.

(2)
Based solely on information set forth in a Schedule 13G filed with the SEC on January 11, 2021 by FMR LLC, reporting that FMR LLC (i) beneficially owned 1,186,089 shares; (ii) had the sole power to dispose or direct the disposition of 1,186,089 shares; and (iii) had the
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sole power to vote or to direct the vote of 332,096 shares. Fidelity Management & Research Company LLC (“FMR Co. LLC”) beneficially owns five percent or greater of the outstanding shares reported in this filing. Abigail P. Johnson is a Director, the Chairman and the Chief Executive Officer of FMR LLC. Members of the Johnson family, including Abigail P. Johnson, are the predominant owners, directly or through trusts, of Series B voting common shares of FMR LLC, representing 49% of the voting power of FMR LLC. The Johnson family group and all other Series B shareholders have entered into a shareholders' voting agreement under which all Series B voting common shares will be voted in accordance with the majority vote of Series B voting common shares. Accordingly, through their ownership of voting common shares and the execution of the shareholders' voting agreement, members of the Johnson family may be deemed, under the Investment Company Act of 1940, to form a controlling group with respect to FMR LLC. Neither FMR LLC nor Abigail P. Johnson has the sole power to vote or direct the voting of the shares owned directly by the various investment companies registered under the Investment Company Act (“Fidelity Funds”) advised by FMR Co. LLC, a wholly owned subsidiary of FMR LLC, which power resides with the Fidelity Funds' Boards of Trustees. FMR Co. LLC carries out the voting of the shares under written guidelines established by the Fidelity Funds' Boards of Trustees. This information reflects the securities beneficially owned, or that may be deemed to be beneficially owned, by FMR LLC, certain of its subsidiaries and affiliates, and other companies (collectively, the “FMR Reporters”). This information does not reflect securities, if any, beneficially owned by certain other companies whose beneficial ownership of securities is disaggregated from that of the FMR Reporters in accordance with Securities and Exchange Commission Release No. 34-39538 (January 12, 1998). The address of the entities and individuals listed above is 245 Summer Street, Boston, Massachusetts 02210.
(3)
Consists of (i) 689,890 shares of common stock held by N. Anthony Coles, M.D., (ii) 97,170 shares of common stock issuable upon exercise of options and warrants within 60 days of April 9, 2021 and (iii) 52,669 shares held by Coles 2016 Irrevocable Trust. Dr. Coles is a trustee of the Coles 2016 Irrevocable Trust and may be deemed to have voting and investment power over shares held by Coles 2016 Irrevocable Trust.
(4)
Based solely on a Schedule 13G filed with the SEC on January 5, 2021. Consists of (i) 548,895 shares of common stock held by Alexandria Venture Investments, LLC (“AVI”), (ii) 7,798 shares of common stock underlying immediately exercisable warrants held by AVI and (iii) 224,341 shares of common stock held directly by Alexandria Equities No. 7, LLC (“AE7”). Each of AVI and AE7 are indirect, wholly-owned subsidiaries of Alexandria Real Estate Equities, Inc. (“ARE”) and, accordingly, ARE may be deemed to share voting and dispositive power with AVI and AE7 with respect to the shares reported herein. The address for the entities is 26 North Euclid Avenue, Pasadena, California 91101.
(5)
Based solely on a Schedule 13G filed with the SEC on February 16, 2021. Redmile Group, LLC’s beneficial ownership of common stock is comprised of (i) 611,003 shares of common stock, and (ii) 62,546 shares of common stock issuable upon exercise of certain warrants to purchase common stock, which are owned by certain private investment vehicles and/or separately managed accounts managed by Redmile Group, LLC, and which may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles and/or separately managed accounts. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any. The address of Redmile Group, LLC is One Letterman Drive, Building D, Suite D3-300, San Francisco, California 94129.
(6)
Based solely on a Schedule 13G filed with the SEC on January 4, 2021. The shares are owned directly by Merck Sharp & Dohme Corp. (“MSD”), which is a wholly owned subsidiary of Merck & Co., Inc. (“Merck”). Merck is an indirect beneficial owner of the reported securities. The address of MSD is One Merck Drive, Whitehouse Station, New Jersey 08889. The address for Merck is 2000 Galloping Hill Road, Kenilworth, NJ 07033.
(7)
Consists of 259,207 shares of common stock issuable upon exercise of options exercisable within 60 days of April 13, 2020 and (ii) 80,615 shares of our common stock.

9, 2021.

(4)(8)

Consists of (i) 121,157Includes 55,873 shares of common stock issuable upon the exercise of options exercisable within 60 days of April 13, 2020 and (ii) 22,915 shares of our common stock.

9, 2021.

(5)(9)

Consists of (i) 185,000Includes 68,768 shares of common stock issuable upon the exercise of options exercisable within 60 days of April 13, 2020 and (ii) 24,520 shares of our common stock.

(6)

Dr. Lee’s9, 2021. Ms. Chhabra’s employment with us terminated effective Julyon December 22, 2019.

2020.

(7)(10)

Consists of (i) 136,19818,363 shares of common stock issuable upon the exercise of options exercisable within 60 days of April 13, 2020 and (ii) 266,162 shares of our common stock.

9, 2021. Ms. Wilson’s employment with us terminated on August 27, 2020.

(8)(11)

Consists of (i) 102,411 shares of common stock, and (ii) 150,073Includes 19,230 shares of common stock issuable upon the exercise of options exercisable within 60 days of April 13, 2020, each held directly by Jeffery W. Kelly. This amount excludes 26,933 shares9, 2021. Dr. Zecevic’s employment with us terminated on December 22, 2020.

(12)
Consists of our common stock held by The Scripps Research Institute. Dr. Kelly is currently a scientist and board member of The Scripps Research Institute. Dr. Kelly disclaims beneficial ownership of the shares held by The Scripps Research Institute except to the extent of his pecuniary interest arising as a result of his employment by The Scripps Research Institute.

(9)

Consists17,766 shares of common stock issuable upon the exercise of options exercisable within 60 days of April 13, 2020.

9, 2021.

(10)(13)

Includes 2,083,0725,271 shares of common stock issuable upon the exercise of options exercisable within 60 days of April 13, 2020.

9, 2021.
(14)
Consists of 2,400 shares of common stock issuable upon exercise of options exercisable within 60 days of April 9, 2021.
(15)
Includes 2,400 shares of common stock issuable upon exercise of options exercisable within 60 days of April 9, 2021.
(16)
Includes 13,070 shares of common stock issuable upon exercise of options exercisable within 60 days of April 9, 2021.
(17)
Includes 5,271 shares of common stock issuable upon exercise of options exercisable within 60 days of April 9, 2021.
(18)
Consists of 17,766 shares of common stock issuable upon exercise of options exercisable within 60 days of April 9, 2021.
(19)
Includes 537,286 shares of common stock issuable upon exercise of options and warrants exercisable within 60 days of April 9, 2021.

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EXECUTIVE OFFICERS

The following table sets forth information with respect to our executive officers as of the date of this Proxy Statement.

Name
​​
Age
​​
Position(s)

Name

N. Anthony Coles, M.D.
​Age​
60
​

Position(s)

​
Executive Chair of the Board of Directors

Meenu Chhabra

Richard Peters, M.D., Ph.D
​​47
58
​​
President, Chief Executive Officer interim Principal Financial Officer and Director

Geoffrey S. Gilmartin,

Paulash Mohsen
​​
47
​​
Chief Business Officer
Brigitte Robertson, M.D., M.M.Sc.

​​52
58
​​
Chief Medical Officer

Benito Munoz, M.Sc.

Ajay Verma, M.D., Ph.D.

​​58
59
​​Chief Scientific Officer

Marija Zecevic, Ph.D.

47Chief Commercial Officer

Sheila Wilson

62Chief Operating Officer
Executive Vice President, Head of Research & Development

Meenu Chhabra.

N. Anthony Coles, M.D. Biographical information for Ms. ChhabraDr. Coles is presented above under the caption “Nominees“Director Nominees and Continuing Directors – Nominees for Election as a Class IIIII Directors for a Three-Year Term Expiring at the 20232024 Annual Meeting.”

Geoffrey S. Gilmartin,

Richard Peters, M.D., M.M.Sc.Ph.D. Biographical information for Dr. GilmartinPeters is presented above under the caption “Director Nominees and Continuing Directors – Continuing Directors.”
Paulash Mohsen has been servingserved as our Chief Business Officer since the completion of the merger of Proteostasis and Yumanity, Inc. in December 2020 and has served as the Chief Business Officer of Yumanity, Inc. since May 2015. Prior to joining Yumanity, from 2013 to 2015, he served as Country Manager in Canada for Cubist Pharmaceuticals, which was acquired by Merck & Co., Inc. Previously, Mr. Mohsen served as Vice President, Strategy and Business Operations for Optimer Pharmaceuticals from 2011 to 2013, which was acquired by Cubist. Prior to Cubist, Mr. Mohsen held strategic and operational roles of increasing responsibility at Pfizer from 1997 to 2011, including Vice President of Strategy and Vice President, Multi-Channel Management. Mr. Mohsen holds a B.S. in chemical engineering from Brown University, an M.S. in chemical engineering from the Massachusetts Institute of Technology and an M.B.A. from Harvard Business School.
Brigitte Robertson, M.D. has served as our Chief Medical Officer since the completion of the merger of Proteostasis and Yumanity, Inc. in December 2020 and has served as the Chief Medical Officer of Yumanity, Inc. since November 2019. Prior to Yumanity, Dr. Robertson served as the Vice President, Therapeutic Area Head Neuroscience, Global Clinical Development at Takeda Pharmaceuticals, Inc. (formerly Shire Plc) from December 2015 to August 2019. From July 20192014 to December 2015, Dr. Robertson served as the Chief Medical Officer at Neurovance, Inc. Previously, Dr. Robertson was the Global Development Strategy Team Lead, Senior Medical Director at Shire from March 2010 to July 2014. Before joining Shire, Dr. Robertson held senior roles at Sunovion Pharmaceuticals from 2006 to 2010 in clinical development and experimental medicine, and at GlaxoSmithKline from 2002 to 2006 in the Center for Excellence in Drug Discovery. Prior to her career in industry, Dr. Robertson held faculty positions at Duke University and University of North Carolina, CCP Children’s Hospital in San Diego, and served as our Chief Medical Affairs Officerin the military. She earned a B.S. with honors at Georgia State University and an MD from February 2019 to July 2019the University of Health Sciences Georgia. Dr. Robertson then completed her residency training in neuropsychiatry at the University of Colorado Health Sciences Center and as our Chief Development Officer from August 2016 to February 2019. From January 2014 to August 2016, he held positions of increasing responsibility at AstraZeneca plc, and most recentlysubsequently served as senior medical leadthe Chief resident during her subspecialty training in global medicines development forchild and adolescent neuropsychiatry at the benralizumab Phase 3 programUniversity of California in severe asthma. From January 2011 to January 2014, he held positionsSan Diego. Dr. Robertson then completed an NIH research fellowship in neuroimaging and psychopharmacology, also at the University of increasing responsibility at Vertex Pharmaceuticals Incorporated including serving as medical lead for the Kalydeco® (ivacaftor) clinical development program, spearheading the initiation of Phase 3 trials to support label expansion studies for the drug. In addition to his leadership positionsCalifornia in the life sciences industry, Dr. Gilmartin is an attending physician in the intensive care unit at Beth Israel Deaconess Medical Center and formerly served as director of the BIDMC Sleep Disorders Center and on its pulmonary leadership team. Dr. Gilmartin received a B.A. in History from Dartmouth College, aSan Diego.
Ajay Verma, M.D. from Brown University School of Medicine and a Master of Medical Science in clinical research from Harvard Medical School.

Benito Munoz, M.Sc., Ph.D.Dr. Munoz has been serving as our Chief Scientific Officer since March 2017, having served as our Executive Vice President, Head of Research and Development since April 2021. Dr. Verma previously served in multiple roles at Codiak Biosciences, Inc. from July 2019 to April 2021, most recently as Executive Vice President, Research and Experimental Medicine. Previously, he was the Chief Medical Officer at United Neuroscience from January 2017 to December 2018, focusing on vaccines for neurological disorders. Prior to that, Dr. Verma was the Vice President of Neurology Drug Discovery and Development at Biogen from September 2016July 2010 to March 2017. Previously,January 2017, where he helped spark neurodegeneration therapeutic efforts by building disease area strategy, clinical development teams, experimental medicine capabilities and novel imaging technologies as well as a neurology drug development fellowship program in conjunction with Massachusetts General Hospital. Prior to joining Biogen, Dr. Munoz served as our Senior Vice President, Drug Discovery from December 2015 to August 2016 and as our Vice President, Medicinal Chemistry from November 2013 to December 2015. From February 2009 to November 2013, he served as the Director of Medicinal Chemistry, Molecular Libraries Probe Productions Center Network, at the Broad Institute, a biomedical research institute affiliated with Harvard University and the Massachusetts Institute of Technology. In his role at the Broad Institute, Dr. Munoz was responsible for designing and implementing a phenotypic screening platform to identify active molecules within Broad’s collection of small molecules which generated potent hits with a therapeutic potential in neglected diseases. From October 1999 to October 2008, he served in a number ofVerma held leadership positions of increasing responsibility at Merck & Co., most recentlyInc. and Novartis Pharmaceuticals and was a US Army Lt. Colonel and Professor of Neurology at the US military’s medical school, the Uniformed Services University of the Health Sciences. He also worked as a Director of Research Laboratories at Merck & Co.’s Boston, Massachusetts laboratories. He formerly served on the board of Karyopharm Therapeutics, Inc. Dr. Munoz received his Ph.D. in Organic Chemistry from the University of Toronto and an M.Sc. in Chemistry from Brock University. He also completed postdoctoral trainingstaff neurologist at the Scripps Research Institute.

Marija Zecevic, Ph.D.Walter Reed Army Medical Center for 11 years after completing his neurology residency there. Dr. Zecevic has been serving as our Chief Commercial Officer since February 2019, and previously served as our Chief Operating Officer from February 2018 to February 2019. Previously, Dr. Zecevic served as our Chief Business Officer from March 2017 to February 2018 and Vice President of Business Development from August 2016 to March 2017. From April 2009 to July 2016, she served as Founder and Managing Director of Zebra Ventures Srl., which firm provided business development consulting services for Proteostasis from August 2014 to July 2016. During her tenure as the Managing Director, she also served as the Founder and Coordinator of the Industry Liaison Office of the Italian Cystic Fibrosis Foundation and as the Acting Head of Business Development of Allozyne Inc. Prior to joining Zebra Ventures Srl., Dr. Zecevic served as the Business Development Manager of BioXell SpA from October 2005 to March 2009 and as Staff Scientist

from March 2003 to September 2005. Dr. ZecevicVerma received a B.S. in Molecular BiologyZoology from the University of Belgrade in Serbia, a Ph.D. in Biochemistry from the Institute of Physiology at the University of Zurich, Switzerland,Maryland College Park and a Masters in International Healthcare Management,M.D. and Ph.D. from the Bocconi School of Management in Milan, Italy.Johns Hopkins University.

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Sheila Wilson, Ms. Wilson has served as our Chief Operating Officer since February 2019, and previously served as our Senior Vice President, Clinical Development Operations from February 2018 to February 2019 and as Vice President, Clinical Operations from October 2016 to February 2018. Prior to joining Proteostasis, Ms. Wilson served as Vice President, Global Clinical Operations at Synta Pharmaceuticals (acquired by Madrigal Pharma) from February 2015 to July 2016. Ms. Wilson was Vice President, Global Clinical Operations at Vertex Pharmaceuticals Incorporated from March 2010 to October 2013 where she was responsible for managing clinical timelines, risk management, and resource and budget management for a diversified portfolio as part of global clinical operations. From 1986 to 2007, Ms. Wilson held roles of increasing responsibility at Pfizer Pharmaceuticals, Inc., including Vice President, US Medical Operations in which she led a team of approximately 170 medical operations professionals and supported business strategies across diversified therapeutic areas. Ms. Wilson received a B.S. in Nursing (BSN) at City University NY Lehman College and a M.B.A. in Pharmaceutical Marketing from Saint Joseph’s University, Philadelphia, PA.

CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS

Other than compensation arrangements which are described under “Executive Compensation” and “Director Compensation.,Compensation, the following is a summary of transactions and series of similar transactions since January 1, 20182019 to which we were a party or will be a party, in which:

the amounts involved exceeded or will exceed the lesser of $120,000 or 1% of the average of our total assets at year endyear-end for the last two completed fiscal years; and

any of our directors, director nominees, executive officers or holders of more than 5% of our capital stock, or any member of the immediate family of the foregoing persons, had or will have a direct or indirect material interest.

Stockholders’ Agreement

Private Placement
In connection with our private placements,the merger between Proteostasis and Yumanity, Inc., on December 14, 2020, we andentered into a Subscription agreement with certain holdersinvestors (the “Subscription Agreement”) for the sale of 1,460,861 shares of common stock at a purchase price of $23.00 per share, for an aggregate purchase price of approximately $33.6 million (the “Private Placement”). The Private Placement closed on December 22, 2020 following the closing of the merger.
The following table summarizes the purchases of our common stock by related persons:
Investor
​​
Shares of
Common Stock
​​
Total Purchase
Price
Entities affiliated with Fidelity(1)
​​
434,780
​​
$9,999,940.00
Franklin Berger(2)
​​
65,217
​​
$1,500,000.00
(1)
Consists of (i) 19,530 shares held by Fidelity Mt. Vernon Street Trust: Fidelity Series Growth Company Fund, (ii) 106,446 units held by Fidelity Mt. Vernon Street Trust: Fidelity Growth Company Fund, (iii) 115,573 shares held by Fidelity Growth Company Commingled Pool, (iv) 19,318 units held by Fidelity Mt. Vernon Street Trust: Fidelity Growth Company K6 Fund, (v) 173,913 shares held by Fidelity Select Portfolios: Biotechnology Portfolio.
(2)
Franklin Berger is a former member of the board directors of Proteostasis.
In connection with the Subscription Agreement, we entered into a stockholders’registration rights agreement with the Purchasers pursuant to which these stockholders will have,we agreed to prepare and file a registration statement with the SEC within 60 days after the closing of the Private Placement for the purposes of registering the resale of the Shares (the “Filing Deadline”). We also agreed, among other things, to indemnify the Purchasers, their officers, directors, members, employees and agents, successors and assigns from certain liabilities and to pay fees and expenses (excluding any underwriting discounts and commissions and transfer taxes) incident to our obligations under the registration rights agreement. Pursuant to the Subscription Agreement, we filed a Registration Statement on Form S-3 (File No. 333-252695) with the SEC, which was declared effective on February 11, 2021.
Support Agreements
In connection with the merger between Proteostasis and Yumanity, Inc., Proteostasis, Yumanity, Inc. and Holdings entered into support agreements with certain equityholders of Holdings, pursuant to which, among other things, each of these equityholders agreed, solely in its capacity as a securityholder, to vote all of its Holdings equity interest (a) in favor of (i) the approval and adoption of the merger agreement, (ii) the approval of the Yumanity Reorganization and approval and adoption of any and all agreements, certificates or documents required or deemed necessary or appropriate in connection with the Yumanity Reorganization, (iii) any proposal to adjourn or postpone the meeting if there are not sufficient votes for the adoption of the merger agreement and approval of related transactions on the date on which such meeting is held and (iv) the approval of any other matter necessary to consummate the transactions contemplated by the merger agreement that are considered and voted upon by Holdings’ equityholders, such as the Yumanity Reorganization, and (b) against any “acquisition proposal,” as defined in the merger agreement. Holdings, as the sole stockholder of Yumanity, Inc. before the Yumanity Reorganization, was also party to a support agreement with Proteostasis pursuant to which Holdings agreed to vote a number of its shares proportionate to the outstanding equity interests of Holdings that have voted in favor of (or consented to) the approval and adoption of the merger agreement and approval of the merger, approval of the Yumanity Reorganization or any other matter necessary to consummate the transactions contemplated by the merger agreement and against any “acquisition proposal,” as defined in the merger agreement. The parties to these support agreements include executive officers and
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directors of Yumanity, Inc. and Holdings and certain entities who directly owned at least 5% of Yumanity, Inc.’s outstanding stock following the Yumanity Reorganization.
In connection with the merger between Proteostasis and Yumanity, Inc., Proteostasis, Yumanity, Inc. and Holdings also entered into support agreements directors and officers of Proteostasis, pursuant to which, among other things, each of these stockholders agreed, solely in his or her capacity as a stockholder, to vote all of his or her shares of Proteostasis common stock (a) in favor of the Proteostasis stockholder proposals and any other matter necessary to consummate the transactions contemplated by the merger agreement and voted on by the Proteostasis stockholders and (b) against any “acquisition proposal,” as defined in the merger agreement.
Upon the completion of the merger between Proteostasis and Yumanity, Inc., the obligations of the parties to the vote their shares as set forth in the support agreements terminated and none of the parties have any remaining rights or obligations under the Securities Actagreements.
Lock-up Agreements
In connection with the merger between Proteostasis and Yumanity, Inc., certain of 1933,Yumanity, Inc.’s then current directors and officers and certain equityholders of Holdings, including Alexandria Equities No. 7, LLC, entities associated with Fidelity, Merck Sharp & Dohme Corp., Biogen New Ventures Inc., N. Anthony Coles, M.D. and certain trusts affiliated with the estate of Susan Lindquist, Ph.D., have agreed to not sell, pledge, or otherwise transfer shares of the combined organization for a period of 180 days following completion of the merger.
Yumanity Reorganization
Immediately prior to completing the merger between Proteostasis and Yumanity, Inc., we completed a series of transactions pursuant to which Holdings, the sole stockholder and holding company parent of Yumanity, Inc. (formerly Yumanity Therapeutics, Inc.) merged with and into Yumanity, Inc. and Yumanity, Inc. continued to exist as amended,the surviving corporation (the “Yumanity Reorganization”). In connection with respectthe Yumanity Reorganization, by operation of law, Yumanity, Inc. acquired all assets of Holdings and assumed all of its liabilities and obligations. Additionally, all securities of Holdings were converted into and became securities of Yumanity, Inc.
Merck Collaboration Agreement
In June 2020, we entered into an exclusive license and research collaboration agreement (the “Merck Collaboration Agreement”) with Merck Sharp & Dohme Corp. (“Merck”), pursuant to commonwhich we granted Merck an exclusive worldwide license under certain intellectual property related to two certain undisclosed targets in connection with our amyotrophic lateral sclerosis and frontotemporal lobar degeneration programs. As consideration for the licenses granted to Merck under the Merck Collaboration Agreement, Merck paid us a one-time upfront payment and also purchased Class C preferred units of Yumanity Holdings, LLC. Under the terms of the Merck Collaboration Agreement, we are eligible to receive up to $530 million upon achievement of certain research, development and sales milestones as well as tiered royalties on net sales of licensed products.
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Class C Preferred Unit Financing
In June 2020, Holdings issued and sold an aggregate of 5,404,588 Class C preferred units pursuant to a unit purchase agreement at a cash purchase price of $4.0008 per unit for an aggregate purchase price of approximately $21.6 million. Purchasers of Holdings’ Class C preferred units included Holdings’ venture capital fund investors and strategic investors that beneficially owned more than 5% of outstanding Holdings capital stock they hold.

and/or were represented on Holdings’ board of directors at the time of sale of the Class C preferred units. The following table presents the number of shares and the total purchase price paid by these entities:

Investor
​​
Class C
Preferred
Units
​​
Total
Class C
Purchase
Price
Alexandria Equities No. 7, LLC(1)
​​
691,990
​​
$2,768,513.60
Entities affiliated with Fidelity(2)
​​
1,099,780
​​
$4,399,999.83
Entities affiliated with Redmile Group, LLC(3)
​​
499,900
​​
$1,999,999.92
Merck Sharp & Dohme Corp.
​​
2,499,500
​​
$9,999,999.60
N. Anthony Coles, M.D.(4)
​​
249,950
​​
$999,999.96
(1)
Lynne Zydowsky, Ph.D. was a member of Holdings’ board of directors and is the chief science officer of Alexandria Real Estate Equities, Inc., an affiliate of Alexandria Equities No. 7, LLC.
(2)
Consisted of (i) 117,944 units held by Fidelity Mt. Vernon Street Trust: Fidelity Series Growth Company Fund, (ii) 478,304 units held by Fidelity Mt. Vernon Street Trust: Fidelity Growth Company Fund, (iii) 440,788 units held by Fidelity Growth Company Commingled Pool and (iv) 62,744 units held by Fidelity Mt. Vernon Street Trust : Fidelity Growth Company K6 Fund.
(3)
Consisted of (i) 124,975 units held by RAF, L.P. and (ii) 374,925 units held by Redmile Biopharma Investments I, L.P.
(4)
Represented 249,950 units held by the Coles 2016 Irrevocable Trust. N. Anthony Coles, M.D. was a 5% holder of Holdings and a member of Holdings’ board of directors.
Indemnification Agreements

We have entered into indemnification agreements with each of our directors and officers. The indemnification agreements and our amended and restated Certificate of Incorporation and amended and restatedBy-laws require us to indemnify our directors and officers to the fullest extent permitted by Delaware law.

Procedures for Related Party Transactions

We have a written policy that requires all transactions between us and any director, executive officer, holder of 5% or more of any class of our capital stock or any member of the immediate family of, or entities affiliated with, any of them, or any other related persons (as defined in Item 404 of RegulationS-K) or their affiliates, in which the amount involved is equal to or greater than $120,000, be approved in advance by our Audit Committee. Any request for such a transaction must first be presented to our Audit Committee for review, consideration and approval. In approving or rejecting any such proposal, our Audit Committee is to consider the relevant facts and circumstances available and deemed relevant to the Audit Committee, including, but not limited to, the extent of the related party’s interest in the transaction, and whether the transaction is on terms no less favorable to us than terms we could have generally obtained from an unaffiliated third party under the same or similar circumstances.

Prior to our Board of Directors’ consideration of a transaction with a related person, the material facts as to the related person’s relationship or interest in the transaction are disclosed to our Board of Directors, and the transaction is not approved by our Board of Directors unless a majority of the directors approved the transaction.
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CORPORATE GOVERNANCE

Management Following the Merger
Prior to December 22, 2020, we were a clinical-stage biopharmaceutical company known as Proteostasis Therapeutics, Inc. (“Proteostasis”). On December 22, 2020, we completed our merger whereby a wholly-owned subsidiary of Proteostasis merged with and into Yumanity, Inc. (formerly Yumanity Therapeutics, Inc.), with Yumanity, Inc. surviving as a wholly-owned subsidiary of Proteostasis (such transactions, the “Merger”). In connection with the completion of the Merger, Proteostasis was renamed Yumanity Therapeutics, Inc. (“Yumanity”).
Prior to the Merger, Yumanity, Inc. was led by Richard Peters, M.D., Ph.D. as President and Chief Executive Officer and its board of directors was composed of: N. Anthony Coles, M.D., Richard Peters, M.D., Ph.D., Patricia L. Allen, Richard A. Heyman, Ph.D., Jeffery W. Kelly, Ph.D., Cecil B. Pickett, Ph.D. and Lynne Zydowsky, Ph.D. In connection with the Merger, the following Yumanity, Inc. officers joined Yumanity’s management team: N. Anthony Coles, M.D., as Executive Chair of the Board of Directors, Richard Peters, M.D., Ph.D. as President and Chief Executive Officer, Paulash Mohsen, as Chief Business Officer and Brigitte Robertson, M.D. as Chief Medical Officer.
Post-Merger, the combined company is led by Richard Peters, M.D., Ph.D. as President and Chief Executive Officer. Our principal executive offices are located at 40 Guest Street, Suite 4410, Boston, Massachusetts 02135. The Board of Directors of Yumanity was composed of N. Anthony Coles, M.D. (Executive Chair), Richard Peters, M.D., Ph.D, Patricia L. Allen, Richard A. Heyman, Ph.D., Cecil B. Pickett, Ph.D. and Lynne Zydowsky, Ph.D. who joined from Yumanity, Inc.’s board of directors, David Arkowitz and Kim C. Drapkin who joined from Proteostasis’ board of directors and Jeffery W. Kelly, Ph.D., who was on both Proteostasis’ and Yumanity’s boards of directors.
Board and Committee Matters

Board Leadership and Independence. Our Board of Directors has determined that all members of the Board of Directors, except Ms. Chhabra,Dr. Peters and Dr. Coles, are independent, as determined in accordance with the rules of The Nasdaq Stock Market. In making such independence determination, the Board of Directors considered the relationships that each suchnon-employee director has with us and all other facts and circumstances that the Board of Directors deemed relevant in determining his or her independence, including the beneficial ownership of our capital stock by eachnon-employee director. In considering the independence of the directors listed above, our Board of Directors considered the association of our directors with the holders of more than 5% of our common stock. There are no family relationships among any of our directors or executive officers.

Board Leadership Structure. The positions of our Chairmanchairman of the Board of Directors (“Chairman of the Board”) and Chief Executive Officer are presently separated. Separating these positions allows our Chief Executive Officer to focus on ourday-to-day business, while allowing the Chairmanchairman of the Board to lead the Board of Directors in its fundamental role of providing advice to and independent oversight of management. Our Board of Directors recognizes the time, effort and energy that the Chief Executive Officer must devote to the position in the current business environment, as well as the commitment required to serve as our Chairmanchairman of the Board, particularly as the Board of Directors’ oversight responsibilities continue to grow. Our Board of Directors also believes that this structure ensures a greater role for thenon-management directors in the oversight of our company and active participation of the independent directors in setting agendas and establishing priorities and procedures for the work of our Board of Directors. Our Board of Directors believes its administration of its risk oversight function has not affected its leadership structure. Although ourBy-laws do not require our Chairmanchairman of the Board and Chief Executive Officer positions to be separate, our Board of Directors believes that having separate positions is the appropriate leadership structure for us at this time.

Code of Business Conduct and Ethics. We have adopted a Code of Business Conduct and Ethics that applies to all of our employees, officers and directors, including those officers responsible for financial reporting. The current version of the Code of Business Conduct and Ethics is available on our website (www.proteostasis.com)(www.yumanity.com) under the Investors & MediaInvestor Relations tab, under thesub-tab “Corporate Governance.” A copy of the Code of Business Conduct and Ethics may also be obtained, free of charge, upon a request directed to: ProteostasisYumanity Therapeutics, Inc., 8040 Guest Street, Suite 500,4410, Boston, Massachusetts 02135 Attention: Secretary. We intend to disclose any amendment or waiver of a provision of the Code of Business Conduct and Ethics that applies to our principal executive officer, principal financial officer, or principal accounting officer, or persons performing similar functions, by posting such information on our website and/or in our public filings with the SEC.
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Corporate Governance Guidelines. The Board of Directors has adopted corporate governance guidelines to assist and guide its members in the exercise of its responsibilities. These guidelines should be interpreted in accordance with any requirements imposed by applicable federal or state law or regulation, Nasdaq and our certificate of incorporation andBy-laws. Our corporate governance guidelines are available in the corporate governance section of our website under the “Investors & Media” tab.“Investor Relations” tab, under the sub-tab “Corporate Governance.” Although these corporate governance guidelines have been approved by the Board of Directors, it is expected that these guidelines will evolve over time as customary practice and legal requirements change. In particular, guidelines that encompass legal, regulatory or exchange requirements as they currently exist will be deemed to be modified as and to the extent that such legal, regulatory or exchange requirements are modified. In addition, the guidelines may also be amended by the Board of Directors at any time as it deems appropriate.

Policy on Trading, Pledging and Hedging of Company Stock. Certain transactions in our securities (such as purchases and sales of publicly traded put and call options, and short sales) create a heightened compliance risk or could create the appearance of misalignment between management and stockholders. In addition, securities held in a margin account or pledged as collateral may be sold without consent if the owner fails to meet a margin call or defaults on the loan, thus creating the risk that a sale may occur at a time when a director or employee is aware of material, non-public information or otherwise is not permitted to trade in Company securities. Our insider trading policy expressly prohibits our executive officers, directors, employees and designated contractors and consultants from engaging in certain prohibited transactions, including short sales, purchases or sales of derivative securities or hedging transactions, the use of our securities as collateral in a margin account, and pledging of our securities.
Board Meetings and Committees. In 2019,2020, our Board of Directors held nine24 meetings, our Audit Committee held four meetings, our Compensation Committee held two meetingsone meeting and our Nominating and Corporate Governance Committee held one meeting. The directors regularly hold executive sessions at meetings of the Board of Directors. During 2019,2020, except for Dr. Kelly, each incumbent member of our incumbent directorsthe Board of Directors attended at least 75% of the aggregate of all meetings of the Board of Directors and all committees of the Board of Directors on which such director served (during the

period that such director served). Dr. Kelly, who was also a director on the Yumanity, Inc. board of directors, did not participate in any discussions relating to potential reverse merger candidates once discussions with Yumanity advanced, and therefore did not attend several meetings of the Board of Directors related to the merger with Yumanity, Inc.

Continuing directors and nominees for election as directors in a given year are required to attendresponsible for attending the annual meeting of stockholders barring significant commitments or special circumstances.to the extent practicable. Ms. Chhabra, Mr. Berger,Arkowitz, Ms. Drapkin, Mr. ArkowitzDr. Dulac and Dr. Kelly from our Board of Directors attended our annual meeting of stockholders held in 2019.

2020.

Stockholder Communications. Any stockholder wishing to communicate with our Board of Directors, a particular director or the chair of any committee of the Board of Directors may do so by sending written correspondence to our principal executive offices, to the attention of the Chair, Nominating and Corporate Governance Committee. All such communications will be delivered to the Board of Directors or the applicable director or committee chair.

Committees
During 2019,2020, our Board of Directors had three standing committees: Audit Committee, Compensation Committee and Nominating and Corporate Governance Committee.

Richard Heyman, Ph.D. has been appointed to serve as our lead independent director. As lead independent director, Dr. Heyman presides over periodic meetings of our independent directors, serves as a liaison between the Executive Chair of the Board of Directors and the independent directors and performs such additional duties as the Board of Directors may otherwise determine and delegate.

Audit Committee. The Prior to the Merger, Proteostasis’ Audit Committee consistswas comprised of Ms.Kim C. Drapkin (Chair), Mr.David Arkowitz, and Dr. Dulac.Emmanuel Dulac, PharmD, Ph.D. In connection with the Merger, Patricia L. Allen (Chair), Kim C. Drapkin, and David Arkowitz were appointed to the Audit Committee. Our Board of Directors has determined that each member of the Audit Committee is “independent” for Audit Committee purposes as that term is defined in the rules of the SEC and the applicable Nasdaq Stock Market rules, and has sufficient knowledge in financial and auditing matters to serve on the Audit Committee. Our Board of Directors has designated Ms. DrapkinAllen as an “audit committee financial expert,” as defined under the applicable rules of the SEC.
The Audit Committee’s responsibilities include:

appointing, approving the compensation of, and assessing the independence of our independent registered public accounting firm;

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pre-approving auditing and permissiblenon-audit services, and the terms of such services, to be provided by our independent registered public accounting firm;

reviewing and approving the overall audit plan with our independent registered public accounting firm and members of management responsible for preparing our financial statements;

reviewing and discussing with management and our independent registered public accounting firm our annual and quarterly financial statements and related disclosures as well as critical accounting policies and practices used by us;

coordinating the oversight and reviewing the adequacy of our internal control over financial reporting;

establishing policies and procedures for the receipt and retention of accounting-related complaints and concerns;

recommending based upon its review and discussions with management and our independent registered public accounting firm whether our audited financial statements shall be included in our Annual Reportannual report on Form10-K;

monitoring the integrity of our financial statements and our compliance with legal and regulatory requirements as they relate to our financial statements and accounting matters;

preparing the Audit Committee report required by SEC rules to be included in our annual proxy statement;

discussing all matters required to be discussed pursuant to applicable accounting rules with our independent registered public accounting firm;

reviewing all related person transactions for potential conflict of interest situations and approving all such transactions; and

reviewing quarterly earnings releases and scripts.

The Audit Committee held four meetings during 2019.2020. The Audit Committee operates under a written charter that satisfies the applicable standards of the SEC and the Nasdaq Stock Market. A copy of the Audit Committee charter is available on our website at www.proteostasis.comwww.yumanity.com under the “Investors & Media”“Investor Relations” tab, under thesub-tab “Corporate Governance.”

Compensation Committee. The Prior to the Merger, the Compensation Committee consistswas comprised of Dr.Jeffery W. Kelly, Ph.D. (Chair) and Mr. Berger.Franklin M. Berger, CFA. In connection with the Merger, Richard A. Heyman, Ph.D. (Chair), Cecil B. Pickett, Ph.D. and Kim C. Drapkin were appointed to the Compensation Committee. Our Board of Directors has determined that each member of the Compensation Committee is “independent” as defined in the applicable Nasdaq Stock Market rules.
The Compensation Committee’s responsibilities include:

annually reviewing and recommending for approval by the Board of Directors,approving the corporate goals and objectives relevant to the future compensation of our Chief Executive Officer;

evaluating the Chief Executive Officer’s performance in light of such goals and objectives and recommending for approval by the Board of Directorsdetermining and approving the compensation of our Chief Executive Officer in light of such evaluation;

annually reviewing, and recommending for approval by the Board of Directors, the goal and performance setting methodology for all company employees;

reviewing and approving the compensation of all other executive officers based on performance against the approved goals;

officers;

appointing, compensating and overseeing the work of any compensation consultant, legal counsel or other adviser retained by the Compensation Committee;

conducting an independence assessment with respect to any compensation consultant, legal counsel or other adviser retained by the Compensation Committee;

reviewing and recommending to our Board of Directors for approvalapproving the compensation of our directors;

reviewing and approving grants and awards under incentive-based compensation and equity-based plans, consistent with the terms of such plans; and

reviewing and discussing with management the compensation disclosure to be included in our annual proxy statement or annual report on Form10-K.

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The Compensation Committee held two meetingsone meeting during 2019.2020. The Compensation Committee operates under a written charter adopted by the Board of Directors, which is available on our website at www.proteostasis.com under the “Investors & Media”“Investor Relations” tab, under thesub-tab “Corporate Governance.”

Following the Merger, our Compensation Committee reviews and approves the compensation to be paid to our Chief Executive Officer and our other executive officers. Our Compensation Committee typically reviews and discusses management’s proposed compensation with the Chief Executive Officer for all executives other than the Chief Executive Officer. In 2020, the Compensation Committee of Proteostasis retained the services of Radford (“Radford”), which is part of the Rewards Solutions practice at Aon plc, as the Compensation Committee’s independent compensation consultant. Radford has advised the Board of Directors and the Compensation Committee on certain compensation matters and decisions. Radford served at the discretion of the Compensation Committee and did not provide any other services to the Company during fiscal year 2020 other than those for which they were engaged by the Compensation Committee. Our Compensation Committee requires that its compensation consultants be independent of Company management and performs an annual assessment of the compensation consultants’ independence to determine whether the consultants are independent. Our Compensation Committee has determined that Radford is independent and that their respective work has not raised any conflicts of interest. The Compensation Committee continued to retain Radford in 2021 in order to ensure that our compensation arrangements are competitive for 2021.
Nominating and Corporate Governance Committee. Our Prior to the Merger, the Nominating and Corporate Governance Committee consistswas comprised of Mr.David Arkowitz (Chair), Ms.Kim C. Drapkin and Dr. Kelly.Jeffery W. Kelly, Ph.D. In connection with the Merger, Cecil B. Pickett, Ph.D. (Chair), David Arkowitz and Lynne Zydowsky, Ph.D. were appointed to the Nominating and Corporate Governance Committee. Our Board of Directors has determined that each member of the Nominating and Corporate Governance Committee is “independent” as defined in the applicable Nasdaq Stock Market rules.
The Nominating and Corporate Governance Committee’s responsibilities include:

developing and recommending to the Board of Directors criteria for Board of Directors and committee membership;

establishing procedures for identifying and evaluating Board of Directors candidates, including nominees recommended by stockholders;

reviewing the size and composition of the Board of Directors to ensure that it is composed of members containing the appropriate skills and expertise to advise us;

identifying individuals qualified to become members of the Board of Directors;

recommending to the board of directors the persons to be nominated for election as directors and to each of the Board of Directors’ committees;

developing and recommending to the Board of Directors a set of corporate governance guidelines;

reviewing and discussing with the Board of Directors corporate succession plans for the chief executive officer and other key officers; and

overseeing the evaluation of the Board of Directors and management.

The Nominating and Corporate Governance Committee held one meeting during 2019.2020. The Nominating and Corporate Governance Committee operates under a written charter adopted by the Board of Directors, which is available on our website at www.proteostasis.comwww.yumanity.com under the “Investors & Media”“Investor Relations” tab, under thesub-tab “Corporate Governance.”

The Nominating and Corporate Governance Committee considers candidates for Board of Director membership suggested by its members and the Chief Executive Officer. Additionally, in selecting nominees for directors, the Nominating and Corporate Governance Committee will review candidates recommended by stockholders in the same manner and using the same general criteria as candidates recruited by the committee and/or recommended by the Board of Directors. Any stockholder who wishes to recommend a candidate for consideration by the committee as a nominee for director should follow the procedures described later in this Proxy Statement under the heading “Stockholder
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“Stockholder Recommendations.” The Nominating and Corporate Governance Committee will also consider whether to nominate any person proposed by a stockholder in accordance with the provisions of ourBy-laws relating to stockholder nominations as described later in this Proxy Statement under the heading “Stockholder Recommendations.”

Identifying and Evaluating Director Nominees. The Board of Directors delegates the selection and nomination process to the Nominating and Corporate Governance Committee, who shall identify and evaluate candidates to serve as directors of the Company (consistent with criteria approved by the Board).

Generally, the Nominating and Corporate Governance Committee identifies candidates for director nominees in consultation with management, through the use of search firms or other advisors, through the recommendations submitted by stockholders or through such other methods as the Nominating and Corporate Governance Committee deems to be helpful to identify candidates. Once candidates have been identified, the Nominating and Corporate Governance Committee confirms that the candidates meet all of the minimum qualifications for director nominees established by the Nominating and Corporate Governance Committee. The Nominating and Corporate Governance Committee may gather information about the candidates through interviews, detailed questionnaires, comprehensive background checks or any other means that the Nominating and Corporate Governance Committee deems to be appropriate in the evaluation process. The Nominating and Corporate Governance Committee then meets as a group to discuss and evaluate the qualities and skills of each candidate, both on an individual basis and taking into account the overall composition and needs of the Board of Directors. Based on the results of the evaluation process, the Nominating and Corporate Governance Committee recommends candidates for the Board of Director’s approval as director nominees for election to the Board of Directors.

Minimum Qualifications. The Nominating and Corporate Governance Committee will consider, among other things, the following qualifications, skills and attributes when recommending candidates for the Board of Director’s selection as nominees for the Board of Directors and as candidates for appointment to the Board of Director’s committees. The nominee shall have the highest personal and professional integrity, shall have demonstrated exceptional ability and judgment, and shall be most effective, in conjunction with the other nominees to the Board of Directors, in collectively serving the long-term interests of the stockholders.

In evaluating proposed director candidates, the Nominating and Corporate Governance Committee may consider, in addition to the minimum qualifications and other criteria for Board of Directors membership approved by the Board of Directors from time to time, all facts and circumstances that it deems appropriate or advisable, including, among other things, the skills of the proposed director candidate, his or her depth and breadth of

professional experience or other background characteristics, factors such as character, integrity, judgment, diversity and length of service, his or her independence and the needs of the Board of Directors.

Stockholder Recommendations. Stockholders may submit recommendations for director candidates to the Nominating and Corporate Governance Committee by sending the individual’s name and qualifications to our Secretary at ProteostasisYumanity Therapeutics, Inc., 8040 Guest Street, Suite 500,4410, Boston, Massachusetts 02135, who will forward all recommendations to the Nominating and Corporate Governance Committee. The Nominating and Corporate Governance Committee will evaluate any candidates recommended by stockholders against the same criteria and pursuant to the same policies and procedures applicable to the evaluation of candidates proposed by directors or management.

Stockholder Communications. The Board of Directors provides to every securityholder the ability to communicate with the Board of Directors, as a whole, and with individual directors on the Board of Directors through an established process for securityholder communication. For a securityholder communication directed to the Board of Directors as a whole, securityholders may send such communication to the attention of the Chairman of the Board via U.S. Mail or Expedited Delivery Service to: ProteostasisYumanity Therapeutics, Inc., 8040 Guest Street, Suite 500,4410, Boston, Massachusetts 02135, Attn: Chairman of the Board.

For a securityholder communication directed to an individual director in his or her capacity as a member of the Board of Directors, securityholders may send such communication to the attention of the individual director via U.S. Mail or Expedited Delivery Service to: ProteostasisYumanity Therapeutics, Inc., 8040 Guest Street, Suite 500,4410, Boston, Massachusetts 02135, Attn: [Name of Individual Director].
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We will forward by U.S. Mail any such securityholder communication to each director, and the Chairman of the Board in his or her capacity as a representative of the Board of Directors, to whom such securityholder communication is addressed to the address specified by each such director and the Chairman of the Board, unless there are safety or security concerns that mitigate against further transmission.

Risk Oversight. Risk assessment and oversight are an integral part of our governance and management processes. Our Board of Directors oversees the management of risks inherent in the operation of our business and the implementation of our business strategies. Our Board of Directors performs this oversight role by using several different levels of review. In connection with its reviews of the operations and corporate functions of our company, our Board of Directors addresses the primary risks associated with those operations and corporate functions. In addition, our Board of Directors reviews the risks associated with our company’s business strategies periodically throughout the year as part of its consideration of undertaking any such business strategies.

The Board of Directors does not have a standing risk management committee, but rather administers this oversight function directly through the Board of Directors as a whole, as well as through various standing committees of the Board of Directors that address risks inherent in their respective areas of oversight. Throughout the year, senior management reviews these risks with the Board of Directors at regular Board meetings as part of management presentations that focus on particular business functions, operations or strategies, and presents the steps taken by management to mitigate or eliminate such risks. Each of the committees of our Board of Directors also oversees the management of our risk that falls within the committee’s areas of responsibility. In performing this function, each committee has full access to management, as well as the ability to engage advisors. Our Audit Committee has the responsibility to consider and discuss our major financial risk exposures and the steps our management has taken to monitor and control these exposures, including guidelines and policies to govern the process by which risk assessment and management is undertaken. Our Audit Committee is responsible for overseeing our major financial and cyber-security risk exposures and the steps our management has taken to monitor and control these exposures. The Audit Committee also monitors compliance with legal and regulatory requirements and considers and approves or disapproves any related person transactions. Our Compensation Committee assesses and monitors whether any of our compensation policies and programs has the potential to encourage excessive risk-taking. The Board of Directors does not believe that its role in the oversight of our risks adversely affects the leadership of the Board of Directors.

In carrying out their risk oversight functions, the Board of Directors and its committees routinely request and review management updates, reports from the independent auditors and legal and regulatory advice from outside experts, as appropriate, to assist in discerning and managing important risks that may be faced by us. The Board of Directors is committed to continuing to ensure and evolve its risk oversight practices as appropriate given the stage of our evolution as a biopharmaceutical company and the fast-paced changes of the life sciences industry. Regarding theCOVID-19 pandemic, our management is meeting regularly to address concerns of our employees and business, as well as updating and communicating with the Board of Directors on a regular basis. The Board of Directors has oversight and has been engaged concerning the monitoring and identification of risks to our Company, and actions we are taking to mitigate risks related to this pandemic.

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Report of the Audit Committee

The information contained in this report shall not be deemed to be (1) “soliciting material,” (2) “filed” with the SEC, (3) subject to Regulations 14A or 14C of the Exchange Act, or (4) subject to the liabilities of Section 18 of the Exchange Act. This report shall not be deemed incorporated by reference into any of our other filings under the Exchange Act or the Securities Act, except to the extent that we specifically incorporate it by reference into such filing.

The Audit Committee oversees our financial reporting process on behalf of the Board of Directors. Management is responsible for our internal controls, financial reporting process, and compliance with laws and regulations and ethical business standards. PricewaterhouseCoopers LLP is responsible for performing an independent audit of our financial statements in accordance with the standards of the Public Company Accounting Oversight Board (United States). The Audit Committee’s main responsibility is to monitor and oversee this process.

The Audit Committee reviewed and discussed our audited financial statements for the fiscal year ended December 31, 2019,2020, with management. The Audit Committee discussed with PricewaterhouseCoopers LLP the matters required to be discussed by the applicable requirements of the Public Company Accounting Oversight Board (“PCAOB”) and the SEC. The Audit Committee has received the written disclosures and the letter from the independent registered public accounting firm required by applicable requirements of the PCAOB regarding the independent registered public accounting firm’s communications with the Audit Committee concerning independence, and has discussed with the independent registered public accounting firm the independent registered public accounting firm’s independence.

Based on the review and discussions referred to above, the Audit Committee recommended to the Board of Directors that such audited financial statements be included in our Annual Report on Form10-K for the year ended December 31, 20192020.
​​
THE AUDIT COMMITTEE
​​
​​
Patricia L. Allen (Chair)
​​
Kim C. Drapkin, CPA
​​
David Arkowitz
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TABLE OF CONTENTS

THE AUDIT COMMITTEE

Kim C. Drapkin, CPA

Emmanuel Dulac, PharmD, Ph.D.

David Arkowitz

EXECUTIVE COMPENSATION

Compensation Overview

This compensation discussion, which should be read together with the compensation tables set forth below,section provides information regarding the total compensation awarded to, earned by, or paid to during the years ended December 31, 20182019 and 20192020 to (1) each individual who served as our principal executive officer, (2) our two next most highly compensated executive officers who earned more than $100,000 during the fiscal year ended December 31, 20192020 and were serving as executive officers as of such date, and (3) any individual who would otherwise be included in (2) above but for the fact that such individual was not serving as an executive officer of ours as of December 31, 2019.2020. We refer to these individuals in this Proxy Statement as our named executive officers.

Our named executive officers for 20192020 who appear in the Summary Compensation Table are:

Meenu Chhabra, our President and Chief Executive Officer,

Marija Zecevic,Richard Peters, M.D., Ph.D., our Chief CommercialExecutive Officer;

Sheila Wilson, our Chief Operating Officer; and

Po-Shun Lee,N. Anthony Coles, M.D., our former Executive Vice President andChair;

Paulash Mohsen, our Chief Medical Officer.

Business Officer;

Our executive compensation program is administered by our Compensation Committee in consultation with our Board of Directors. The key objectives of our executive compensation program are (1) to attract, motivate, reward and retain superior executive officers with

Meenu Chhabra, the skills necessary to successfully lead and manage our business; (2) to achieve accountability for performance by linking annual cash incentive compensation to the achievement of measurable performance objectives; and (3) to align the interests of our executive officers and our stockholders through short- and long-term incentive compensation programs. For our executive officers, these short- and long-term incentives are designed to accomplish these objectives by providing a significant correlation between our results of operations and their total compensation.

Setting Executive Compensation

Our Compensation Committee is responsible for reviewing and determining the compensation of our executive officers, and, with respect to ourformer Chief Executive Officer recommending compensation for determination byof Proteostasis;

Marija Zecevic, the full Boardformer Chief Commercial Officer of Directors. We have not adopted any formal guidelines for allocating total compensation between long-termProteostasis; and short-term compensation, cash compensation andnon-cash compensation, or among different forms
Sheila Wilson, the former Chief Operating Officer ofnon-cash compensation.

Role of the Compensation Committee

The Compensation Committee, which is comprised entirely of independent directors, reviews and approves, or with respect to our Chief Executive Officer, recommends to the full Board of Directors for approval, Proteostasis.

To date, the compensation packages for our named executive officers, including an analysis of all elements of compensation separately and in the aggregate.

In reviewing and approving, or making recommendations with respect to, these matters, our Compensation Committee considers such matters as it deems appropriate, including our financial and operating performance, the alignment of the interests of our executive officers and our stockholders and our ability to attract and retain qualified and committed individuals, as well as each executive officer’s performance, experience, responsibilities and the compensation of executive officers in similar positions at comparable companies. In determining its recommendations for the appropriate compensation levels for our Chief Executive Officer, the Compensation Committee meets outside the presence of all our executive officers. With respect to the compensation levels of all other executive officers, the Compensation Committee meets outside the presence of all executive officers except our Chief Executive Officer. Our Chief Executive Officer annually reviews the performance of each of the other named executive officers with the Compensation Committee.

Role of Compensation Consultant

In 2019, we engaged Radford (“Radford”), an independent executive compensation consultant, to provide guidance with respect to the development and implementation of our compensation programs.

Our Compensation Committee charter requires that any compensation consultants engaged by the Compensation Committee be independent of company management. During 2019, Radford did not provide services to us other than the services described in this Proxy Statement. Under its charter, our Compensation Committee is responsible for performing an annual assessment of any compensation consultants’ independence to determine whether the consultants are independent. Our Compensation Committee has determined that Radford is independent and that their work has not raised any conflicts of interest.

Elements of Compensation

Base Salary

Our Compensation Committee reviews the base salaries of our executive officers, including our named executive officers, from time to time and makes adjustments as it determines to be reasonable and necessary to reflect the scope of an executive officer’s performance, contributions, responsibilities, experience, prior salary level, position (in the case of a promotion) and market conditions.

The following table sets forth the annual base salaries for each of our named executive officers for 2019 and 2020.

NAME

  2019
BASE SALARY
($)		  2020
BASE SALARY
($)

Meenu Chhabra

  539,600  566,580

Sheila Wilson.

  358,100  376,005

Marija Zecevic, Ph.D..

  364,000  382,200

Po-Shun Lee, M.D. (1)

  360,706  N/A

(1)

Dr. Lee’s employment with us was terminated effective July 22, 2019.

Non-Equity Incentive Plan Compensation

We believe thathas consisted of a significant portioncombination of our executives’ compensation should be based on the attainment of business goals recommended by the Compensation Committee and approved by the Board of Directors while also rewarding individual performance. Each named executive officer is eligible for an annual incentive bonus pursuant to our Senior Executive Cash Incentive Bonus Plan, which is approved annually.

Under the 2019 Senior Executive Cash Incentive Bonus Plan, each named executive officer was eligible to be considered for an annual performance bonus based on the percentage attainment, as determined by the Board of Directors upon recommendation from the Compensation Committee, of (1) our 2019 corporate goals established by the Board of Directors, upon recommendation of the Compensation Committee in its sole discretion and communicated to each officer and (2) the 2019 individual goals established by the Board of Directors, upon recommendation of the Compensation Committee. Our 2019 corporate goals established by the Board of Directors, upon recommendation of the Compensation Committee included achievement of topline data in differing doses of nesolicaftor(PTI-428), posenacaftor(PTI-801), and doricaftor(PTI-808), and achievement of regulatory milestones for our proprietary combination therapies, initiatives to improve corporate culture and the extension of our cash runway. The Compensation Committee retained the discretion to make adjustments to the calculated bonus based on unexpected or unplanned events, the overall financial condition of the Company, extraordinary performance or underperformance or other factors as determined appropriate by the Compensation Committee. Each named executive officer has a target bonus opportunity and may earn more or less than the annual target amount based on our company’s and his or her individual performance.

The Board of Directors, upon the recommendation of the Compensation Committee, determined that the percentage attainment of our corporate goals for 2019 was 100%. After review of individual performance achievement targets, the Board of Directors determined that each of Ms. Chhabra, Ms. Wilson and Dr. Zecevic shall be granted a 2019 performance bonus equal to 110% of her target bonus percentage of her base salary, as reflected in the column of the Summary Compensation Table abovetitled “Non-Equity Incentive Plan Compensation.”

NAME

  2019
BONUS
TARGET
(%)		  2019
INCENTIVE
BONUS
PAID
($)		   2020
BONUS
TARGET
(%)

Meenu Chhabra

  50   296,780   50

Sheila Wilson.

  30   157,564   40

Marija Zecevic, Ph.D.

  35   160,160   40

Po-Shun Lee, M.D. (2)

  40   80,245   N/A

(2)

Dr. Lee’s employment with us was terminated effective July 22, 2019; however, pursuant to the terms of his separation agreement, he remained eligible for apro-rated bonus under our Senior Executive Cash Incentive Bonus Plan as he served as a consultant to us from July 23, 2019 to December 25, 2019.

Equity-Based Awards

Equity-basedbonuses and long-term incentive compensation is an integral part of our overall compensation program. Providing named executive officers with the opportunity to create significant wealth through stock ownership is a powerful tool to attract and retain highly qualified executives, achieve strong long-term stock price performance and align our executives’ interests with those of our stockholders. In addition, equity awards serve as an additional retention measure. Additional grants may occur periodically in order to specifically incentivize executives with respect to achieving certain corporate goals or to reward executives for exceptional performance. We have historically granted equity awards to our employees, including our named executive officers, in the form of stock options to purchase shares of our commonand restricted stock.

Retirement Benefits and Other Compensation

Our named executive officers, did not participate in, or otherwise receive any benefits under, any pension or nonqualified deferred compensation plan sponsored by us during 2019. Our named executive officers werelike all full-time employees, are eligible to participate in our employee benefits, including health insurance and group life insurance benefits, on the same basis as our other employees. We maintain a 401(k) plan intended to qualify as atax-qualified plan under Section 401 of the U.S. Internal Revenue Code of 1986, as amended, which our named executive officers are eligible to participate in on the same basis as our other employees. We generally do not provide perquisites or personal benefits except in limited circumstances, and we did not provide any perquisites or personal benefits to our named executive officers in 2019.

welfare benefit plans.

20192020 Summary Compensation Table

The following table presents information regarding the total compensation awarded to, or earned by, and paid to each individual who served as one of our named executive officers for services rendered to us in all capacities during the fiscal years indicated.

Name and Principal Position

 Year  Salary
($)		  Option
Awards (1)
($)		  Non-Equity
Incentive Plan
Compensation (2)
($)		  All Other
Compensation (3)
($)		  Total ($) 

Meenu Chhabra

  2019   539,600   1,135,941   296,780   8,400   1,980,721 

President, and
Chief Executive Officer

  2018   515,000   516,770   257,500   —     1,783,730 

Sheila Wilson(4)

  2019   358,100   424,887   157,564   6,300   946,851 

Chief Operating Officer

      

Marija Zecevic, Ph.D.(5)

  2019   364,000   424,847   160,160   6,300   955,307 

Chief Commercial Officer

      

Po-Shun Lee, M.D.(6)

  2019   225,705   441,478   80,245(7)   239,903(8)   987,331 

Former Executive Vice President and Chief Medical Officer

  2018   360,706   160,815   126,247   —     783,070 

year ended December 31, 2020.
Name and Principal Position(1)
​​
Year
​​
Salary ($)
​​
Stock
Awards(2)
​​
Option
Awards
($)(3)
​​
Non-Equity
Incentive Plan
Compensation
($)(4)
​​
All Other
Compensation
($)
​​
Total ($)
N. Anthony Coles
Executive Chair of the Board of Directors
​​
2020
​​
390,000
​​
—
​​
42,046(5)
​​
312,000
​​
—
​​
744,046
​
2019
​​
469,211
​​
—
​​
291,375
​​
170,703
​​
—
​​
931,289
Richard Peters, M.D., Ph.D.(6)
Chief Executive Officer
​​
2020
​​
600,000
​​
—
​​
238,739(5)
​​
480,000
​​
1,956(7)
​​
1,320,695
​
2019
​​
195,769
​​
—
​​
3,536,984
​​
83,312
​​
1,965
​​
3,818,022
Paulash Mohsen
Chief Business Officer
​​
2020
​​
374,764
​​
—
​​
151,724(5)
​​
205,000
​​
1,733(7)
​​
733,221
​
2019
​​
357,108
​​
—
​​
—
​​
94,277
​​
4,915
​​
456,300
Meenu Chhabra
Former Chief Executive Officer
​​
2020
​​
560,043
​​
267,288
​​
1,583,177(8)
​​
—
​​
857,902(9)
​​
3,268,410
​
2019
​​
539,600
​​
—
​​
1,135,941
​​
296,780
​​
8,400
​​
1,980,721
Marija Zecevic
Former Chief Commercial Officer
​​
2020
​​
377,790
​​
145,898
​​
505,811(8)
​​
—
​​
390,565(10)
​​
1,420,065
​
2019
​​
364,000
​​
—
​​
424,847
​​
160,160
​​
6,300
​​
955,307
Sheila Wilson
Former Chief Operating Officer
​​
2020
​​
237,172
​​
—
​​
158,747(8)
​​
—
​​
388,224(11)
​​
784,144
​
2019
​​
358,100
​​
—
​​
424,887
​​
157,564
​​
6,300
​​
946,851
(1)

AmountsUpon the completion of the merger of Proteostasis and Yumanity, Inc. in December 2020, Ms. Chhabra, Dr. Zecevic and Ms. Wilson resigned from their respective positions at Proteostasis.

(2)
The amounts reported represent the aggregate grant-dategrant date fair value of option awardsrestricted stock units granted to ourthe named executive officers in theduring fiscal year indicated, computed2020, calculated in accordance with Financial Accounting Standards Board, (“FASB”)or FASB Accounting Standards Codification, (“ASC”)or ASC Topic 718 excluding718. Such grant date fair value does not take into account any estimatesestimated forfeitures. The assumptions used in calculating the grant date fair value of forfeitures related to service-based vesting conditions. For information regarding assumptions underlying the valuation of equity awards seereported in this column are set forth in Note 912 to our financial statements included in our Annual Report on Form10-K for the year ended December 31, 20192020 filed with the SEC on March 10, 2020. TheseThe amounts doreported in this column reflect the accounting cost for the restricted stock units and does not correspond to the actual economic value that may be recognizedreceived upon settlement of the restricted stock units or any sale of any of the underlying shares of common stock.
(3)
The amounts reported represent the aggregate grant date fair value of the stock options awarded to the named executive officers during fiscal year 2020 and 2019, calculated in accordance with Financial Accounting Standards Board, or FASB Accounting Standards Codification, or
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ASC Topic 718. Such grant date fair value does not take into account any estimated forfeitures. The assumptions used in calculating the grant date fair value of the awards reported in this column are set forth in Note 12 to our financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2020 filed with the SEC on March 10, 2020. These amounts also include the incremental fair value associated with a stock option repricing in 2020. The amounts reported in this column reflect the accounting cost for the stock options and does not correspond to the actual economic value that may be received upon exercise of the stock option or any sale of any of the underlying shares of common stock.
(4)
The amounts in this column represent the amount of compensation earned by the named executive officers upon vesting or exerciseunder the applicable annual performance-based bonus program during each fiscal year.
(5)
Amounts are inclusive of the applicable awards.

incremental fair value of certain options repriced in 2020.

(2)(6)

Dr. Peters commenced employment with Yumanity in September 2019. Dr. Peters’ base salary and annual bonus for the 2019 calendar year have each been prorated to reflect his start date and partial year of service.

(7)
Amount represents reimbursement of parking costs and the gross-up of taxes paid on such reimbursement amounts.
(8)
Amounts are inclusive of the incremental fair value associated with the extension of the post-termination exercise period. See “—Narrative Disclosure to Summary CompensationTable—Non-Equity Table — Separation Agreements Incentive Plan Compensation” above” below for a description of the material termsoption extension.
(9)
Amount represents (i) $849,870 in severance and (ii) $8,032 in employer 401(k) matching contributions. See “— Narrative Disclosure to Summary Compensation Table — Separation Agreements” below for a description of the program pursuantseverance terms.
(10)
Amount represents (i) $382,200 in severance and (ii) $8,365 in employer 401(k) matching contributions. See “— Narrative Disclosure to which this compensation was awarded.

Summary Compensation Table — Separation Agreements” below for a description of the severance terms.

(3)(11)

Amounts represent

Amount represents (i) $381,787 in severance and (ii) $6,437 in employer 401(k) matching contributions. See “— Narrative Disclosure to Summary Compensation Table — Separation Agreements” below for a fifty (50) percent contribution match by Proteostasis up to six (6) percentdescription of annual eligible compensation under our 401(k) plan effective January 1, 2019, which all of our named executive officers were eligible to receive.

the severance terms.

(4)

Ms. Wilson was not one of our named executive officers for the fiscal year ended December 31, 2018.

(5)

Dr. Zecevic was not one of our named executive officers for the fiscal year ended December 31, 2018.

(6)

Dr. Lee’s employment with us terminated effective July 22, 2019. He remained as a consultant from July 23, 2019 to December 25, 2019.

(7)

Represents apro-rated bonus under our Senior Executive Cash Incentive Bonus Plan, which Dr. Lee remained eligible to receive pursuant to the terms of his separation agreement.

(8)

Represents (i) severance payments totaling $144,282, (ii) consulting fees in the amount of $450 pursuant to the terms of his separation agreement, (iii) a cash payment for unused accrued vacation through his separation date in the amount of $9,281, (iv) incremental fair value associated with acceleration of stock options of $1,228 and (v) legal fees paid by us on Dr. Lee’s behalf in the amount of $14,597.

Narrative Disclosure to Summary Compensation Table

Outstanding Equity Awards at 2019 FiscalYear-End Table

Executive Compensation Elements

The following table presentsdescribes the outstanding equity awards heldmaterial terms of the elements of our executive compensation program during 2020, including while a private company prior to the merger with Proteostasis in December 2020. The compensation provided to the former executive officers of Proteostasis reflect the compensation decisions made by eachProteostasis’ board of directors and compensation committee made prior to the closing of the merger of Proteostasis and Yumanity, Inc., and do not reflect compensation decisions of our Board of Directors.
Annual Base Salary
Our Board of Directors and Compensation Committee recognize the importance of base salary as an element of compensation that helps to attract and retain the named executive officers. We provide a base salary as a fixed source of income for our named executive officers as offor the services they provide to us during the year, which allows us to maintain a stable executive team.
The base salaries for our named executive officers in effect for the year ended December 31, 2019.2020 were as follows: $390,000 for Dr. Coles, $600,000 for Dr. Peters, and $374,764 for Mr. Mohsen.
Annual Cash Incentive
We also provide our named executive officers with annual performance-based cash bonus opportunities, calculated based upon the achievement of specified corporate goals, with each executive officer being assigned a corporate and individual goal weighting. For fiscal year 2020, each executive officer was assigned a target bonus opportunity, which is reflected as a percentage of that individual’s 2020 base salary and is based on the individual’s role and title in the Company.
For fiscal year 2020, the target bonus opportunity as a percentage of 2020 base salary and corporate and individual goal weighting for each of Dr. Peters and Mr. Mohsen is as follows:
Name
​​
Target Bonus
(% of Base
Salary)
​​
Corporate
Goal
Weighting (%)
​​
Individual
Goal
Weighting (%)
N. Anthony Coles, M.D.
​​
50
​​
100
​​
—
Richard Peters, M.D.
​​
50
​​
100
​​
—
Paulash Mohsen
​​
35
​​
80
​​
20
Following fiscal year 2020, our Compensation Committee determined that we had achieved 160% of our corporate goals for 2020. Bonuses paid with respect to 2020 performance were pro-rated for any partial year of employment and were paid, if applicable, during the first quarter of 2021.
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       Option Awards         

Name

  Vesting
Commencement
Date		   Securities
Underlying
Unexercised
Options(1)
(#)
Exercisable		   Securities
Underlying
Unexercised
Options(1)
(#)
Unexercisable		   Option
Exercise
Price		   Option
Expiration
Date		 

Meenu Chhabra

   6/6/2014    360,068    —     $3.36    6/6/2024 
   10/8/2015    110,875    —   $14.71    10/8/2025 
   2/10/2016    152,682    10,179   $8.00    2/10/2026 
   4/3/2017    154,688    70,312   $7.56    4/3/2027 
   3/1/2018    105,350    135,450   $3.11    3/1/2028 
   3/1/2019    —      367,700   $4.30    3/1/2029 

Sheila Wilson

   11/1/2016    45,000    15,000   $6.98    11/1/2026 
   3/1/2017    10,313    4,687   $14.72    3/1/2027 
   3/1/2018    10,500    13,500   $3.11    3/1/2028 
   3/1/2019    —      137,500   $4.30    3/1/2029 

Marija Zecevic, Ph.D.

   11/1/2016    45,500    10,500   $6.98    11/1/2026 
   4/3/2017    41,250    18,750   $7.56    4/3/2027 
   3/1/2018    31,719    40,781   $3.11    3/1/2028 
   3/1/2019    —      137,500   $4.30    3/1/2029 

Po-Shun Lee, M.D.

   6/29/2015    52,727    —     $11.03    6/29/2025 
   2/10/2016    99,926    —     $8.00    2/10/2026 
   4/3/2017    52,050    —     $7.56    4/3/2027 
   3/1/2018    37,400    —     $3.11    3/1/2028 
   3/1/2019    35,725    —     $4.30    3/1/2029 

(1)

Each stock option was granted pursuant to our 2008 Equity Incentive Plan (the “2008 Plan”) or our 2016 Stock Option and Incentive Plan (the “2016 Plan”). The shares of common stock underlying these stock options vest over a four-year period, with 25% of the shares vesting upon the completion of one year of service measured from the vesting commencement date, and the balance vesting in 12 successive equal quarterly installments upon the completion of each additional three-month period of service thereafter, subject to the named executive officer’s continued service through each such vesting date. Dr. Lee’s options were accelerated on July 22, 2019 in connection with the termination of his employment.

Equity Compensation
Our Board of Directors considers equity incentives to be important in aligning the interests of the named executive officers with those of its equityholders. As part of our pay-for-performance philosophy, our compensation program tends to emphasize the long-term equity award component of total compensation packages paid to our named executive officers. In determining the size of the equity incentives to be awarded to our named executive officers, we take into account a number of internal factors, such as the relative job scope, the value of existing long-term incentive awards, individual performance history, prior contributions and anticipated future contributions to us and the size of prior grants. Originally, we had granted incentive units intended to constitute “profits interests” to compensate our employees. More recently, we have granted options to compensate its named executive officers. We have granted equity incentives both in the form of initial grants in connection with the commencement of employment and periodic refresher grants. Because employees are able to profit from options only if our price increases relative to the option’s exercise price, we believe options in particular provide meaningful incentives to employees to achieve increases in the value of our equity over time. While we intend that the majority of equity awards to our employees be made pursuant to initial grants or periodic refresh grants, our Board of Directors retains discretion to grant equity awards to employees at other times, including in connection with the promotion of an employee, to reward an employee, for retention purposes or for other circumstances recommended by management or our Board of Directors. The exercise price of each option grant is the fair market value of our common stock on the grant date. We do not have any stock ownership requirements for our named executive officers.
Employment Arrangements with our Named Executive Officers

Agreements

We have entered into an employment agreementagreements with each of our named executive officers. Except as noted below, these employment agreements provide for “at will” employment.N. Anthony Coles, M.D., Richard Peters, M.D., Ph.D. and Paulash Mohsen. The agreements set forth the initial terms and conditions of the executive’s employment with us, includingnamed executive officer’s initial base salary, bonus opportunity,potential, eligibility for employee benefits and severance benefits upon a qualifying termination of employment, subject to certainnon-solicitation andnon-competition provisions. Any provisions and confidentiality obligations. The key terms of our employment arrangements with our 2020 named executive officers, including potential payments and benefits due upon a qualifying termination of employment or a change in control, are further described below.
These employment agreements provide for “at will” employment. The terms “change of control,” “cause” and “good reason” referred to below under “— Potential Paymentsare defined in the applicable employment agreement.
N. Anthony Coles, M.D.
Dr. Coles currently serves as our Executive Chair of our Board of Directors. He is entitled to an annual base salary, currently $401,700, and Benefits upon Termination or Changean annual target bonus equal, currently 50% of his base salary, as determined by our Board of Directors in Control.”

Meenu Chhabra. On October 21, 2016,its sole discretion. Prior to serving as our Executive Chair, we entered into an amended and restated employment agreement with Ms. Chhabra,Dr. Coles as well as an agreement containing certain non-solicitation and non-competition provisions and confidentiality obligations in connection with her continuinghis services as our Chief Executive Officer.

Effective as of our 2021 annual meeting of stockholders, Dr. Coles will transition to the role of Non-Executive Chair. Following this transition, he will receive an annual retainer of $300,000 per year and will not be eligible to receive an annual cash bonus for such service. Dr. Coles’ cash compensation for 2021 will be prorated for the period of time Dr. Coles serves as Executive Chair and Non-Executive Chair of the Board of Directors.
Richard Peters, M.D., Ph.D.
We entered into an employment agreement with Richard Peters, M.D., Ph.D., our President and Chief Executive Officer. ThisOfficer, on June 30, 2019. Under the terms of his employment agreement, replaced her letterDr. Peters is entitled to receive an annual base salary and an annual target bonus, as determined by our Board of Directors in its sole discretion. Dr. Peters also entered into an employee confidentiality, assignment and noncompetition agreement dated April 4, 2014with us, the terms of which are incorporated into his employment agreement. Under such employee confidentiality, assignment and noncompetition agreement, to the letter agreement dated March 10, 2016. Theextent that the 12 month post-employment noncompetition restrictions is enforced, Dr. Peters is entitled to receive garden leave payments during such 12 month period equal to 50% of his highest annualized base salary that we paid to him within the two-year period preceding his last day of employment.
Dr. Peters’ employment agreement provides for an initial base salary and annual cash bonus pursuant to our Senior

Executive Cash Incentive Bonus Plan, as it may be amended from time to time, with an individual target bonus opportunity. The agreement also provides for certain change in control and severance agreements described below under “—Potential Payments Upon Termination or Change in Control.” Ms. Chhabra’s compensation has been subsequently increased to the amounts described above.

Sheila Wilson. On March 9, 2020, we entered into an amended and restated employment agreement with Ms. Wilson, in connection with her employment as our Chief Operating Officer. This agreement superseded her letter agreement dated September 29, 2016 and letter agreement dated May 18, 2017. The employment agreement provides for an initial base salary and annual cash bonus pursuant to our Senior Executive Cash Incentive Bonus Plan, as it may be amended from time to time, with an individual target bonus opportunity. The agreement also provides for certain change in control and severance agreements described below under “—Potential Payments Upon Termination or Change in Control.” Ms. Wilson’s compensation has been subsequently increased to the amounts described above.

Marija Zecevic, Ph.D. On March 9, 2020, we entered into an amended and restated employment agreement with Dr. Zecevic, in connection with her continuing role as our Chief Commercial Officer. This agreement superseded her letter agreement dated May 14, 2016 and letter agreement dated March 8, 2017. The employment agreement provides for an initial base salary and annual cash bonus pursuant to our Senior Executive Cash Incentive Bonus Plan, as it may be amended from time to time, with an individual target bonus opportunity. The agreement also provides for certain change in control and severance agreements described below under “—Potential Payments Upon Termination or Change in Control.” Dr. Zecevic’s compensation has been subsequently increased to the amounts described above.

Potential Payments Upon Termination or Change of Control

We have entered into post-employment compensation arrangements with Ms. Chhabra, Ms. Wilson and Dr. Zecevic.

Meenu Chhabra. Pursuant to her employment agreement, as amended in October 2016,that, in the event that herhis employment is terminated by us without “cause” (as such term is defined in her agreement) or she terminates her employment with usby Dr. Peters for “good reason” (as such term is defined in her agreement), in either case priorsubject to a “change in control” (as such term is defined in her agreement) or at any time prior to or at any time after the first anniversaryexecution and effectiveness of a changeseparation agreement and release, which shall include, without limitation and in control, sheour sole discretion, a one-year post-employment

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noncompetition agreement, he will be entitled to receive:receive (i) an amount equal to 12 months of his base salary continuationplus one times his target bonus for that year, payable in substantially equal installments in accordance with our payroll practice over 12 months followingcommencing within 60 days after the date of termination (provided, that in the event Dr. Peters is entitled to any payments pursuant to his employee confidentiality, assignment and noncompetition agreement, such severance amounts received in any calendar year will be reduced by the amount that Dr. Peters is paid in the same calendar year pursuant to his employee confidentiality, assignment and noncompetition agreement), and (ii) a monthly cash paymentreimbursement of COBRA premiums for health benefit coverage, in an amount equal to the monthly employer contribution that we would have made to provide health insurance to Ms. ChhabraDr. Peters had shehe remained employed with us until the earlier of 12 months following the date of termination or the date Ms. Chhabrathat Dr. Peters becomes eligible for health benefits through another employer or otherwise becomes ineligible for COBRA.
Under Dr. Peters’ employment agreement, in the event that Dr. Peters is terminated by us without “cause” or by Dr. Peters for “good reason” within 12 months after a change in control, then in lieu of the payments and benefits described above and subject to the execution and effectiveness of a separation agreement and release, he will be entitled to receive (i) an amount equal to two times his then current base salary (or, his base salary in effect immediately prior to the change in control, if higher) plus two times his target bonus for that year, payable in a lump sum within 60 days after the date of termination (provided, that in the event Dr. Peters is entitled to any payments pursuant to his employee confidentiality, assignment and noncompetition agreement, such severance amounts will be reduced by the amount that Dr. Peters is paid or to be paid in the same calendar year pursuant to his employee confidentiality, assignment and noncompetition agreement), (ii) reimbursement of COBRA premiums for health benefit coverage, in an amount equal to the monthly employer contribution that we would have made to provide health insurance to Dr. Peters had he remained employed with us until the earliest of 18 months following the date of termination or the date that Dr. Peters becomes eligible for health benefits through another employer or otherwise becomes ineligible for COBRA, and (iii) onacceleration of 100% of the datestock options and other stock-based awards held by Dr. Peters that is 35 days afterare subject to solely time-based vesting and the milestone option award granted to Dr. Peters in connection with the commencement of his employment, as of the later of the date of termination and the portioneffective date of any outstanding equity grantsthe separation agreement and release.
The payments and benefits provided to Dr. Peters in connection with a change in control may not be eligible for a federal income tax deduction for us pursuant to Section 280G of the U.S. Internal Revenue Code of 1986, as amended, or the Code, and may subject Dr. Peters to an excise tax under Section 4999 of the Code. If the payments or benefits payable to Dr. Peters in connection with a change in control would be subject to time-based vestingthe excise tax on golden parachutes imposed under Section 4999 of the Code, then those payments or benefits will be reduced if such reduction would result in a higher net after-tax benefit to Dr. Peters.
Paulash Mohsen
We entered into an employment agreement with Paulash Mohsen, our Chief Business Officer, on April 8, 2015. Under the terms of his employment agreement, Mr. Mohsen is entitled to receive an annual base salary and an annual target bonus, determined by our Board of Directors in its sole discretion. Mr. Mohsen also entered into a confidentiality and noncompetition agreement with us, the terms of which are incorporated into his employment agreement.
Mr. Mohsen’s employment agreement provides that, would have vested in the 12 months following the date of termination had she remained employed will vest. In the event that Ms. Chhabra obtains employment during the period during which she is receiving severance payments, any remaining severance payments will be reduced by the amount of any cash compensation she received pursuant to such employment during the severance period. In the event that herhis employment is terminated by us without cause,“cause” at any time or she terminates her employment with usby Mr. Mohsen for good reason, in either case“good reason” within 12 months following a change inof control, shesubject to the execution and effectiveness of a separation agreement and release, he will be entitled to receive:receive (i) an amount equal to nine months of his base salary, continuationpayable in accordance with our normal payroll practices for 18a period of nine months, following termination,and (ii) a monthly cash paymentreimbursement of COBRA premiums for health benefit coverage, in an amount equal to the monthly employer contribution that we would have made to provide health insurance to Ms. ChhabraMr. Mohsen had shehe remained employed bywith us until the earlierearliest of 18nine months following the date of termination or the date that Mr. Mohsen becomes reemployed.
Separation Agreements
Meenu Chhabra
In connection with the merger between Proteostasis and Yumanity, Inc., Proteostasis entered into a retention agreement with Meenu Chhabra, effective December 21, 2020, pursuant to which she was issued a restricted stock unit award valued at $283,290. In addition, all of her stock options with exercise prices above $7.00 were canceled, and the exercise period for all of her remaining vested stock options was extended until the earlier of (i) 18 months following the closing of the merger and (ii) the original expiration date of such options.
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In connection with the retention agreement, we also amended certain terms of Ms. Chhabra’s employment agreement, pursuant to which Ms. Chhabra is entitled to receive (i) severance pay of $849,870, representing 18 months of her base salary, payable in a lump sum following the date of termination and (ii) if elected, continued benefits coverage pursuant to COBRA (of the employer’s portion of the premium cost) for up to 18 months or, if earlier, until the date that Ms. Chhabra becomes eligible for health benefits through another employer or otherwise becomes ineligible for COBRA, and (iii) on the date that is 35 days after the date of termination, accelerated vesting ofCOBRA. In addition, 100% of theMs. Chhabra’s then outstanding unvested equity awards held by Ms. Chhabra that arewas subject to time-based vesting.vesting immediately vested and became exercisable and not subject to forfeiture. We havealso agreed to waive the option to condition receipt of the severancenon-competition provision under her employee proprietary information, inventions, non-competition, non-solicitation agreement. In exchange for such payments, accelerated equity vesting and benefits described above uponother consideration, Ms. Chhabra entering intoprovided us with a release, in favor of us, of any and not revoking a separation agreement with us, including a general release of claims.

Sheila Wilson andMarija Zecevic, Ph.D.On March 9, 2020, we entered into amended and restated employment agreements with Ms. Wilson and Dr. Zecevic. Pursuantall claims relating to these agreements, in the event that the named executive officer’s employment is terminated by us without “cause” (as such term is defined in the agreement) or a named executive officer terminates her employment with usus.

Marija Zecevic
In connection with the merger between Proteostasis and Yumanity, Inc., Proteostasis entered into a retention agreement with Marija Zecevic, effective December 21, 2020, pursuant to which she was issued a restricted stock unit award valued at $152,880. In addition, all of her stock options with exercise prices above $7.00 were canceled, and the exercise period for “good reason” (as such term is defined in the agreement), in either case prior to a “change in control” (as such term is defined in the agreement) or at any time prior to or within twelve months following a change in control, the named executive officer will be entitled to receive: (i) base salary continuation for nine months following termination, (ii) a monthly cash payment in an amount equal to the monthly contribution that we would have made to provide health insurance to the named executive officer had the named executive officer remained employedall of her remaining vested stock options was extended until the earlier of nine(i) 18 months following the closing of the merger and (ii) the original expiration date of such options.
In connection with the retention agreement, certain terms of Dr. Zecevic’s employment agreement were also amended, pursuant to which Dr. Zecevic received (i) severance pay of $382,200, representing 12 months of her base salary, payable in a lump sum following the date of termination and (ii) if elected, continued benefits coverage pursuant to COBRA (of the employer’s portion of the premium cost) for up to 12 months or, if earlier, until the date the named executive officerthat Dr. Zecevic becomes eligible for health benefits through another employer or otherwise becomes ineligible for COBRA, and (iii) on the dateCOBRA. In addition, 100% of Dr. Zecevic’s then outstanding unvested equity that is 35 days after the date of termination, the portion of any outstanding equity grantswas subject to time-based vesting that would haveimmediately vested and became exercisable and not subject to forfeiture. We also agreed to waive the non-competition provision under her employee confidential information and invention assignment agreement. In exchange for such payments, accelerated equity vesting and other consideration, Ms. Chhabra provided us with a release, in the nine months following the datefavor of termination had the named executive officer remained employed will accelerateus, of any and vest. In the event that Ms. Wilson’s or Dr. Zecevic’s employment is terminated by us without cause, or they terminateall claims relating to her employment with us for good reason, in either case within 12 months following change in control, they will be entitled to receive: (i) base salary continuation for 12 months following termination, (ii) a monthly cash payment in an amount equal to the monthly contribution that we would have made to provide health insurance to Ms.us.
Sheila Wilson and Dr. Zecevic had they remained employed by us until the earlier of 12 months following the date of termination or the date they become eligible for health benefits through another employer or otherwise become ineligible for COBRA, and (iii) on the date that is 35 days after the date of termination, acceleration of 100% of the equity awards held by Ms. Wilson and Dr. Zecevic that are subject to time-based vesting. In the event that a named executive officer obtains employment during the period during which she is receiving severance payments, any remaining severance payments will be reduced by the amount of any cash compensation received by the named executive officer pursuant to such employment during the severance period. Receipt of the severance payments and benefits described above is conditioned upon the named executive officer entering into and not revoking a separation agreement with us, including a general release of claims.

Ms. Chhabra has entered into an Employee Proprietary Information, Inventions,Non-Competition andNon-Solicitation Agreement that contains, among other things,non-competition andnon-solicitation provisions that apply during the term of the named executive officer’s employment and for 12 months thereafter. In addition, Ms. Wilson and Dr. Zecevic have entered into an Employee Confidential Information, Inventions,Non-Competition andNon-Solicitation Agreements (“CIIA”) that contain, among other things,non-competition andnon-solicitation provisions that apply during the term of the named executive officer’s employment and for 12 months thereafter. If we elect to enforce thenon-competition provision in either of the CIIAs that we entered into with Ms. Wilson or Dr. Zecevic, then we will be required to either: (i) accelerate the vesting of stock options held by the executive by 12 months; or (ii) pay continuing salary payments to the executive for one year following termination of employment at a rate equal to no less than 50% of the highest annualized base salary paid to the executive within the two years prior to the date of termination.

Separation Agreement and Consulting Agreement withDr. Po-Shun Lee

Effective July 22, 2019, Dr. Lee stepped down from his position as our Chief Medical Officer. In connection with the termination of his employment, we

On August 24, 2020, Proteostasis entered into a separation agreement and general release dated July 22, 2019 with Dr. Lee (the “Separation Agreement’),Sheila Wilson which among other things, provideswas subsequently revised on November 19, 2020. Pursuant to the separation agreement, provided that Dr. Lee isMs. Wilson has not breached any of her continuing obligations, Ms. Wilson was entitled to the following severance benefits:receive (i) salary continuation for nine months (the “Severance Period”), (ii) a monthly cash payment in an amount equal to 12 months of base salary and (ii) if elected, continued benefits coverage pursuant to COBRA (of the monthly contribution that we would have madeemployer’s portion of the premium cost) for up to provide health insurance to Dr. Lee had he remained employed12 months or, if earlier, until the earlier of nine months or the date he becamethat Ms. Wilson becomes eligible for health benefits through another employer or otherwise becomes ineligible for COBRA, and (iii) continued vestingCOBRA. In addition, the exercise period for Ms. Wilson’s vested stock options was extended until the earlier of all equity awards that would have vested during(i) 18 months following the Severance Period. In connection with the executionclosing of the Separation Agreement, we enteredmerger between Proteostasis and Yumanity, Inc. and (ii) the original expiration date of such options. We also agreed to enter into a Consulting Agreement dated July 23, 2019consulting agreement with Dr. Lee (the “Consulting Agreement’) pursuant to which Dr. Lee providedMs. Wilson and, upon her commencement of such consulting services, to us from July 23, 2019 to December 25, 2019, when the Consulting Agreement was terminated pursuant to its terms. In

exchange for his services pursuant to Consulting Agreement, Dr. Lee (i) received a consulting fee of $450.00 per hour and (ii) was eligible for continued vesting ofgranted her stock options followingon the Severance Period during the period he was providing consulting services. As a consultant, he also remained eligible for apro-rated annual incentive bonus for fiscal year 2019same terms and received a bonus pursuant to the terms of the Senior Executive Cash Incentive Bonus Plan in the amount of $141,910. Dr. Lee’ssame amounts as certain stock options were accelerated on July 22, 2019that Ms. Wilson had forfeited following her separation. Ms. Wilson was also released from the lock-up agreement that she signed in connection with the terminationmerger, and we waived the non-competition provision under her employee confidential information and invention assignment agreement.

In exchange for the payments and other consideration under the separation agreement, Ms. Wilson provided us with a release, in favor of his employment.

Equityus, of any and all claims relating to her employment with us.

Employee Benefit Plans

For more information

401(k) Savings Plan
We maintain a tax-qualified retirement plan that provides eligible employees with an opportunity to save for retirement on a tax-advantaged basis. All participants’ interests in their contributions are 100% vested when contributed. Contributions are allocated to each participant’s individual account and are then invested in selected investment alternatives according to the participants’ directions. The retirement plan is intended to qualify under Section 401(a) of the Code. Matching contributions to the plan are made at the discretion of our current equity compensation programBoard of Directors. No matching contributions were provided in 2020.
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Health and decisions regarding the grantsWelfare Benefits
All of equity awards in fiscal 2019 for our namedfull-time employees, including our executive officers, see “Equity-Based Awards” above.

Sinceare eligible to participate in our health and welfare benefits, including medical, dental and vision insurance, medical and dependent care flexible spending accounts, group life and disability insurance, and 401(k) plan. Named executive officers are eligible to participate in all our employee benefit plans, in each case on the completion ofsame basis as other employees.

We do not offer any defined benefit pension plans or nonqualified defined compensation arrangements for our initial public offering in February 2016, we have granted equity awards to employees, including our named executive officers, under our 2016 Plan. officers.
Outstanding Equity Awards at 2020 Fiscal Year-End
The following table sets forth information concerning outstanding equity awards held by our named executive officers that we granted prior to our initial public offering were granted under our 2008 Plan. Our Boardas of Directors has delegated authority to our Compensation Committee to administer the terms of our 2016 Plan and 2008 Plan. Please refer to the plan documents filed as exhibits to our Annual Report onForm 10-K for the year ended December 31, 2019 filed with the SEC on March 10, 2020 for the terms of such plans.2020.
 
​​
Option Awards
Name
​​
Vesting
Commencement
Date
​​
Number of
Securities
Underlying
Unexercised
Options (#)
Exercisable
​​
Number of Securities
Underlying
Unexercised Options
(#) Unexercisable
​​
Option
Exercise
Price ($)
​​
Option
Expiration
Date
N. Anthony Coles
​​
12/4/2018
​​
72,496(1)
​​
0
​​
8.16
​​
12/8/2028
​​
12/4/2018
​​
12,082(1)
​​
0
​​
8.16
​​
9/9/2029
Richard Peters
​​
9/9/2019
​​
235,238(1)
​​
0
​​
8.16
​​
9/8/20/29
Paulash Mohsen
​​
12/4/2018
​​
42,168(1)
​​
0
​​
8.16
​​
12/8/2028
​​
2/18/2020
​​
10,542(1)
​​
0
​​
8.16
​​
2/17/2030
Meenu Chhabra(2)
​​
6/6/2014
​​
5,968
​​
0
​​
67.20
​​
6/22/2022
​​
6/6/2014
​​
12,035
​​
0
​​
67.20
​​
6/22/2022
​​
3/1/2018
​​
11,288
​​
0
​​
62.20
​​
6/22/2022
​​
3/1/2018
​​
752
​​
0
​​
62.20
​​
6/22/2022
​​
3/1/2019
​​
16,618
​​
0
​​
86.00
​​
6/22/2022
​​
3/1/2019
​​
1,767
​​
0
​​
86.00
​​
6/22/2022
​​
3/2/2020
​​
19,032
​​
0
​​
31.40
​​
6/22/2022
​​
3/2/2020
​​
1,308
​​
0
​​
31.40
​​
6/22/2022
Marija Zecevic(2)
​​
11/1/2016
​​
159
​​
0
​​
139.60
​​
6/22/2022
​​
11/1/2016
​​
2,641
​​
0
​​
139.60
​​
6/22/2022
​​
3/1/2018
​​
2,493
​​
0
​​
62.20
​​
6/22/2022
​​
3/1/2018
​​
1,132
​​
0
​​
62.20
​​
6/22/2022
​​
3/1/2019
​​
5,269
​​
0
​​
86.00
​​
6/22/2022
​​
3/1/2019
​​
1,606
​​
0
​​
86.00
​​
6/22/2022
​​
3/2/2020
​​
4,077
​​
0
​​
31.40
​​
6/22/2022
​​
3/2/2020
​​
1,853
​​
0
​​
31.40
​​
6/22/2022
Sheila Wilson(2)
​​
11/1/2016
​​
100
​​
0
​​
139.60
​​
6/22/2022
​​
11/1/2016
​​
2,712
​​
0
​​
139.60
​​
6/22/2022
​​
3/1/2018
​​
750
​​
0
​​
62.20
​​
6/22/2022
​​
3/1/2019
​​
2,578
​​
0
​​
86.00
​​
6/22/2022
​​
12/3/2020
​​
7,290
​​
0
​​
31.40
​​
6/22/2022
​​
12/3/2020
​​
450
​​
0
​​
62.20
​​
6/22/2022
​​
12/3/2020
​​
4,296
​​
0
​​
86.00
​​
6/22/2022
​​
12/3/2020
​​
187
​​
0
​​
139.60
​​
6/22/2022
(1)
Each option award was fully exercisable upon grant, and vests with respect to 25% of the shares upon the first anniversary of the vesting commencement date, with the remaining shares vesting in 36 equal monthly installments thereafter, in each case subject to the executive’s continuing service relationship. Except for Dr. Peters’ option granted September 9, 2019, the vesting of 100% of shares will be accelerated upon a capital transaction.
(2)
In connection with the merger with Proteostasis in December 2020, all stock options accelerated in full. In addition, each executive entered into an agreement pursuant to which the exercise period for vested stock options was extended until the earlier of (i) 18 months following the closing of the merger between Proteostasis and Yumanity, Inc. and (ii) the original expiration date of such options.
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Compensation Risk Assessment

We believe that although a portion of the compensation provided to our executive officers and other employees is performance-based, our executive compensation program does not encourage excessive or unnecessary risk-taking. This is primarily due to the fact that ourrisk taking. Our compensation programs are designed to encourage our executive officers and other employees to remain focused on both short-term and long-term strategic goals, in particular in connection with ourpay-for-performance compensation philosophy. As a result, we do not believe that our compensation programs are reasonably likely to have a material adverse effect on our company.

Rule10b5-1 Sales Plans

Our policy governing transactions in our securities by directors, officers and employees permits our officers, directors and certain other persons to enter into trading plans complying with Rule10b5-1 under the Exchange Act. Generally, under these trading plans, the individual relinquishes control over the transactions once the trading plan is put into place. Accordingly, sales under these plans may occur at any time, including possibly before, simultaneously with, or immediately after significant events involving our company.

us.

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EQUITYDIRECTOR COMPENSATION PLAN INFORMATION

2020 Director Compensation Table
The following table provides information aboutpresents the securities authorized for issuance undertotal compensation paid by the Company’s equity compensation plansCompany to each person who served as of December 31, 2019:

   Number of
securities to be
issued upon
exercise of
outstanding
options
(a)		  Weighted average
exercise price of
outstanding
options
(b)		   Number of securities
remaining available
for future issuance
under equity
compensation plans
(excluding securities
reflected in column
(a))
(c)		 

Equity compensation plans approved
by security holders (1)

   4,364,839(2)  $5.30    1,459,513(3) 

Equity compensation plans not
approved by security holders

   —   —    — 
  

 

 

    

 

 

 

Totals

   4,364,839     1,459,513 

(1)

Consists of our 2008 Plan, 2016 Plan and 2016 Employee Stock Purchase Plan (the “2016 ESPP”).

(2)

Consists of shares underlying outstanding options under the 2008 Plan and the 2016 Plan.

(3)

Consists of shares available under the 2016 Plan and the 2016 ESPP. The number of shares of common stock reserved for issuance under the 2016 Plan will automatically increase on January 1 of each year, beginning on January 1, 2017 and continuing through and including January 1, 2026, by 3% of the total number of shares of our common stock outstanding on December 31 of the preceding calendar year or a lesser number of shares determined by our Compensation Committee. Pursuant to the terms of the 2016 Plan, effective January 1, 2020, an additional 1,563,498 shares were added to the number of available shares available under the 2016 Plan. The number of shares of common stock reserved for issuance under the 2016 ESPP will automatically increase on January 1 of each year, beginning on January 1, 2017 and continuing through and including January 1, 2026, by the least of (i) 138,757 shares, (ii) 1% of the number of shares of our common stock outstanding on December 31 of the preceding calendar year, or (iii) the number of shares determined by the our Compensation Committee. Pursuant to the terms of the 2016 ESPP, effective January 1, 2020, an additional 138,757 shares were added to the number of available shares available under the 2016 ESPP.

DIRECTOR COMPENSATION

The following table sets forth a summary of the compensation earned for service on our Board of Directors by ournon-employee directors during the year ended December 31, 2019. Other than as set forth in the table and described more fully below, we did not pay any compensation, reimburse any expense of, make any equity awards ornon-equity awards to, or pay any other compensation to any of thenon-employee members member of our Board of Directors during 2019. Ms. Chhabra, our Chief Executive Officer, receives nothe fiscal year ended December 31, 2020. See the section titled “Executive Compensation” for more information on the compensation for her service as a director,paid to or earned by Dr. Coles, Dr. Peters and consequently, is not included in this table. The compensation received by Ms. Chhabra as an employee during 2019 is presented inemployees for the “2019 Summary Compensation Table” earlier in this Proxy Statement.

Name

  Fees Earned or
Paid in Cash
($)		   Option Awards
($)(1)(2)		   All Other
Compensation
($)		  Total
($)		 

David Arkowitz

   36,269    30,600    —     66,869 

M. James Barrett, Ph.D. (3)

   34,711    —      —     34,711 

Franklin M. Berger, CFA

   48,024    15,300    —     63,324 

Kim C. Drapkin, CPA

   49,650    30,600    —     80,250 

Emmanuel Dulac, PharmD, Ph.D.

   35,500    30,600    —     66,100 

Jeffery W. Kelly, Ph.D.

   48,024    15,300    50,000(4)   113,324 

Eric B. Rabinowitz (5)

   5,000    —      —     5,000 

year ended December 31, 2020.
Name
​​
Fees Earned or
Paid in Cash ($)(1)
​​
Option Awards
($)(2)(3)
​​
All Other
Compensation
($)
​​
Total ($)
Patricia Allen
​​
45,134
​​
63,578
​​
—
​​
108,713
Richard A. Heyman
​​
30,403
​​
63,578
​​
—
​​
93,982
Cecil B. Pickett
​​
30,470
​​
63,578
​​
—
​​
94,049
Lynne Zydowsky
​​
30,228
​​
63,578
​​
—
​​
93,807
Jeffery W. Kelly
​​
77,461
​​
79,794
​​
43,889(4)
​​
201,144
David Arkowitz
​​
50,027
​​
16,215
​​
—
​​
66,242
Kim C. Drapkin
​​
53,483
​​
16,215
​​
—
​​
69,698
Franklin M. Berger
​​
63,427
​​
16,215
​​
—
​​
79,643
Badrul A. Chowdhury
​​
34,153
��​
16,215
​​
—
​​
50,369
Emmanuel Dulac
​​
41,472
​​
16,215
​​
—
​​
57,687
(1)

Amounts represent cash compensation for services rendered as a director during 2020.

(2)
The amounts reported represent the aggregate grant-dategrant date fair value of option awardsstock options granted to ourthe non-employee directors in 2019, computedduring fiscal year 2020, calculated in accordance with Financial Accounting Standards Board, or FASB Accounting Standards Codification, or ASC Topic 718 excluding718. Such grant date fair value does not take into account any estimatesestimated forfeitures. The assumptions used in calculating the grant date fair value of forfeitures related to service-based vesting conditions. For information regarding assumptions underlying the valuation of equity awards seereported in this column are set forth in Note 912 to our financial statements included in our Annual Report on Form10-K for the year ended December 31, 20192020 filed with the SEC on March 10, 2020. TheseThe amounts doreported in this column reflect the accounting cost for the stock options and does not correspond to the actual economic value that may be recognized by the directorsreceived upon vestingsettlement of the applicable awards.

restricted stock units or any sale of any of the underlying shares of common stock.

(2)(3)

The following table below shows the aggregate number of option awards outstanding for eachnon-employee director atstock options held by our directors as of December 31, 2019 is as follows:

2020:

Name
​​
Number of Shares Underlying
Outstanding Options

Director

Patricia Allen
​Unexercised Option
Awards (#)​
17,766

David Arkowitz

Richard A. Heyman
​​30,600
5,271

M. James Barrett, Ph.D.

Cecil B. Pickett
​​124,723
5,271

Lynne Zydowsky
​​
17,766
Jeffery W. Kelly
​​
13,835
David Arkowitz
​​
2,400
Kim C. Drapkin
​​
7,871
Franklin M. Berger CFA

​​140,023
2,400

Kim C. Drapkin, CPA

Badrul A. Chowdhury
​​30,600
2,400

Emmanuel Dulac PharmD, Ph.D.

​​30,600

Jeffery W. Kelly, Ph.D.

153,898
2,400

(3)

Dr. Barrett resigned as a director effective June 27, 2019.

(4)

Represents an annual consulting feeAmount represents compensation paid to Dr. Kelley for his service on our scientific advisory board.

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(5)

Mr. Rabinowitz resigned as a director effective January 31, 2019.

Non-Employee Director Compensation Policy

In December 2015,

Following the consummation of the merger of Proteostasis and Yumanity, Inc., we amended and restated our non-employee director compensation policy. Under our director compensation policy, we pay our non-employee directors a cash retainer for service on the Board of Directors and for service on each committee on which the director is a member. This cash compensation is the same as was applicable to the prior policy that had been in effect for Proteostasis. These fees are payable in arrears in four equal quarterly installments on the last day of each quarter, provided that the amount of such payment is prorated for any portion of such quarter that the director is not serving on our Board of Directors. The fees paid to non-employee directors for service on the Board of Directors adopted anon-employee director compensation policy, which became effectiveand for service on February 10, 2016 and which was most recently amended byeach committee of the Board of Directors on February 4,which the director is a member are as follows:
​​
Member
Annual Fee
Board of Directors
​​
$35,000
Audit Committee Chair
​​
15,000
Audit Committee Member
​​
7,500
Compensation Committee Chair
​​
10,000
Compensation Committee Member
​​
5,000
Nominating and Corporate Governance Committee Chair
​​
7,500
Nominating and Corporate Governance Committee Member
​​
3,500
We also reimburse our non-employee directors for reasonable travel and out-of-pocket expenses incurred by our non-employee directors in connection with attending our meetings of the Board of Directors and committees thereof.
In addition to cash compensation, each new non-employee director who is initially appointed or elected to the Board of Directors is eligible to receive a one-time equity award of an option to purchase 14,800 shares of our common stock (the “Initial Grant”), which will vest quarterly over three years following the date of grant, subject to the director’s continued service. In addition, on the date of each annual meeting of stockholders of our company, each non-employee director will be granted an additional option to purchase 7,400 shares of our common stock (the “Annual Grant”), which will vest quarterly over one year following the date of grant. Each Initial Grant and Annual Grant shall accelerate in full upon a Sale Event (as defined in the applicable equity plan).
Each non-employee director who was serving as of the date of the merger of Proteostasis and Yumanity, Inc. in December 2020 that is designedalso entitled to an Initial Grant, but such Initial Grant shall be made on the day of the Company’s annual meeting of stockholders in 2021 in lieu of an Annual Grant.
This program is intended to provide a total compensation package that enables us to attract and retain on a long-term basis, high-calibernon-employee directors.Non-employeequalified and experienced individuals to serve as directors receive a combinationand to align our directors’ interests with those of cash and equity compensation.

Cash Compensation

Under our policy, eachnon-employee director will be paid cash compensation as set forth below, prorated based on days of service during a calendar year:

Annual
Retainer ($)

Board of Directors:

Allnon-employee members

35,000

Additional retainer forNon-Executive Chairperson

25,000

Audit Committee:

Chairperson

15,000

Non-Chairperson members

7,500

Compensation Committee:

Chairperson

10,000

Non-Chairperson members

5,000

Nominating and Corporate Governance Committee:

Chairperson

7,500

Non-Chairperson members

3,500

Equity Compensation

In addition to cash compensation, eachnon-employee director is eligible to receive nonqualified stock options and/or restricted stock unit awards under our 2016 Plan. Any stock options granted under this policy are nonstatutory stock options,stockholders.

EQUITY COMPENSATION PLAN INFORMATION
The following table provides certain information with a term of ten years from the date of grant, subject to earlier termination in connection with a termination of service.

Vesting schedules for equity awards are subject to thenon-employee director’s continuous service on each applicable vesting date. Notwithstanding any vesting schedule, for eachnon-employee director who remains in continuous service with the Company until immediately prior to the closing of a change in control, the shares subject to his or her then-outstanding equity awards that were granted pursuant to this policy will become fully vested prior to a “Sale Event” (as defined in the 2016 Plan).

Initial Award

Each newnon-employee director who is initially appointed or electedrespect to our Boardequity compensation plans in effect as of Directors is eligible to receive aone-time equity award of an option to purchase 34,800 shares of our common stock or a stock option with a grant date fair value of $72,036, whichever has a lower value, which option vests in equal quarterly installments over a period of three years following the grant date, subject to the director’s continued service on our Board of Directors.December 31, 2020:

Name
​​
Number of Securities
to be Issued upon
Exercise of
Outstanding Options,
Warrants and Rights
(a)(#)
​​
Weighted-Average
Exercise Price of
Outstanding Options,
Warrants and Rights
(b)($)
​​
Number of Securities
Remaining Available
for Future Issuance
Under Equity
Compensation Plans
(Excluding Securities
Reflected in Column
(a))(c)(#)
Plan Category
​​
 
​​
 
​​
 
Equity compensation plans approved by security holders(1)
​​
194,550
​​
$68.48
​​
76,225(3)
Equity compensation plans not approved by security holders(2)
​​
750,411
​​
$8.31
​​
776,799
Total
​​
 
​​
 
​​
 
(1)
Includes the Proteostasis Therapeutics, Inc. 2008 Equity Incentive Plan, the Proteostasis Therapeutics, Inc. 2016 Stock Option and Incentive Plan (the “2016 Plan”) and the Proteostasis Therapeutics, Inc. 2016 Employee Stock Purchase Plan (the “ESPP”).
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Annual Award

On the date of each annual meeting of our stockholders, each continuingnon-employee director who has served for at least six months is eligible to receive an annual equity award with of an option to purchase 17,400 shares of our common stock or a stock option with a grant date fair value of $36,018, whichever has a lower value, which option vests in equal quarterly installments over a period of one year following the grant date.

Additional Awards

Ournon-employee directors may also be granted such additional stock options in such amounts and on such dates as our Board of Directors may recommend. All of the foregoing options are granted with an exercise price per share equal to the reported closing price on the date of grant, or the preceding business day if there are not market quotations on such date.

Reimbursement of Expenses

We reimburse allnon-employee directors for reasonableout-of-pocket expenses incurred bynon-employee directors in attending meetings of the Board of Directors or any committee.

(2)
Includes the Yumanity Therapeutics, Inc. Amended and Restated 2018 Stock Option and Grant Plan (the “2018 Plan”). A description of the 2018 Plan is contained in Note 12 of the notes to our consolidated financial statements contained in our Annual Report on Form 10-K for the year ended December 31, 2020, filed with the SEC on March 10, 2021.
(3)
As of December 31, 2020, a total of 322,605 shares of our common stock have been reserved for issuance pursuant to the 2016 Plan, which number excludes the 303,495 shares that were added to the 2016 Plan as a result of the automatic annual increase of 3% on January 1, 2021. As of December 31, 2020, a total of 34,689 shares of our common stock have been reserved for issuance pursuant to the ESPP, which number excludes the 6,937 shares that were added to the 2016 Plan as a result of the automatic annual increase of 1% on January 1, 2021.
HOUSEHOLDING OF PROXY MATERIALS

Some banks, brokers, and other nominee record holders may be participating in the practice of “householding” proxy statements and annual reports. This means that only one copy of the Notice of Internet Availability of Proxy Materials, Proxy Statement, and Annual Report on Form10-K for the year ended December 31, 2019,2020, as applicable, is being delivered to multiple stockholders sharing an address unless we have received contrary instructions. We will promptly deliver a separate copy of any of these documents to you if you write to us at 8040 Guest Street, Suite 500,4410, Boston, MAMassachusetts 02135, Attention: Secretary or call us at(617) 225-0096.409-5300. If you want to receive separate copies of the Notice of Internet Availability of Proxy Materials, Proxy Statement, or Annual Report on Form10-K in the future, or if you are receiving multiple copies and would like to receive only one copy for your household, you should contact your bank, broker, or other nominee record holder, or you may contact us at the above address or telephone number.

STOCKHOLDER PROPOSALS
A stockholder who would like to have a proposal considered for inclusion in our 2022 proxy statement must submit the proposal in accordance with the procedures outlined in Rule 14a-8 of the Exchange Act so that it is received by us no later than December 23, 2021. However, if the date of the 2022 Annual Meeting of Stockholders is changed by more than 30 days from the date of the previous year’s meeting, then the deadline is a reasonable time before we begin to print and send our proxy statement for the 2022 Annual Meeting of Stockholders. SEC rules set standards for eligibility and specify the types of stockholder proposals that may be excluded from a proxy statement. Stockholder proposals should be addressed to Yumanity Therapeutics, Inc., 40 Guest Street, Suite 4410, Boston, Massachusetts 02135, Attention: Corporate Secretary.
If a stockholder wishes to propose a nomination of persons for election to our Board of Directors or present a proposal at an annual meeting but does not wish to have the proposal considered for inclusion in our proxy statement and proxy card, our bylaws establish an advance notice procedure for such nominations and proposals. Stockholders at an annual meeting may only consider proposals or nominations specified in the notice of meeting or brought before the meeting by or at the direction of the Board of Directors or by a stockholder of record on the record date for the meeting, who is entitled to vote at the meeting and who has delivered timely notice in proper form to our corporate secretary of the stockholder’s intention to bring such business before the meeting.
The required notice must be in writing and received by our corporate secretary at our principal executive offices not less than 90 days nor more than 120 days prior to the first anniversary of the preceding year’s annual meeting. However, in the event that the date of the annual meeting is advanced by more than 30 days, or delayed by more than 60 days, from the first anniversary of the preceding year’s annual meeting, a stockholder’s notice must be so received no earlier than the 120th day prior to such annual meeting and not later than the close of business on the later of (A) the 90th day prior to such annual meeting and (B) the tenth day following the day on which notice of the date of such annual meeting was mailed or public disclosure of the date of such annual meeting was made, whichever first occurs. For stockholder proposals to be brought before the 2022 Annual Meeting of Stockholders, the required notice must be received by our corporate secretary at our principal executive offices no earlier than February 2, 2022 and no later than March 4, 2022. Stockholder proposals and the required notice should be addressed to Yumanity Therapeutics, Inc., 40 Guest Street, Suite 4410, Boston, Massachusetts 02135, Attention: Corporate Secretary.
OTHER MATTERS

The Board of Directors knows of no other matters that will be presented for consideration at the Annual Meeting. If any other matters are properly brought before the Annual Meeting, it is the intention of the persons named in the accompanying proxy to vote on such matters in accordance with their best judgment.

By Order of the Board of Directors,

LOGO

Meenu Chhabra

President, and Chief Executive Officer and Director

April 29, 2020

A copy of our Annual Report onForm 10-K for the fiscal year ended December 31, 2019, as filed with the Securities and Exchange Commission, is available without charge upon written request to: Proteostasis Therapeutics, Inc., Attn.: Corporate Secretary, 80 Guest Street, Suite 500, Boston, Massachusetts 02135.

34

LOGO

ANNUAL MEETINGTABLE OF PROTEOSTASIS THERAPEUTICS, INC.CONTENTS

Date:

Monday June 29, 2020

Time:9:00 A.M. (Eastern Time)
Place:80 Guest Street, First Floor, Event Room, Boston, MA 02135

Please make your marks like this:    ☒  Use dark black pencil or pen only

The Board of Directors Recommends a VoteFORthe director nominees listed in Proposal 1 andFOR Proposal 2.

1:

To elect three Class II directors, Meenu Chhabra, Jeffery W. Kelly, Ph.D. and David Arkowitz, to serve until the 2023 annual meeting of stockholders and until their successors are duly elected and qualified, subject to their earlier resignation or removal.

Nominee:

(1) Meenu Chhabra

(2) Jeffery W. Kelly, Ph.D.

(3) David Arkowitz

Vote For

All Nominees

Withhold Vote From

All Nominees

Vote For

All Except

☐☐☐
INSTRUCTIONS: To withhold authority to vote for any nominee, mark the “Exception” box and write the number(s) in the space provided to the right

ForAgainstAbstain

2:

To ratify the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2020.☐

☐

☐
To transact such other business as may properly come before the Annual Meeting or at any adjournments or postponements thereof
To attend the meeting and vote your sharesin person, please mark this box.☐
Authorized Signatures - This section must becompleted for your Instructions to be executed.

Please Sign HerePlease Date Above

Please Sign HerePlease Date Above

Please sign exactly as your name(s) appears on your stock certificate. If held in joint tenancy, all persons should sign. Trustees, administrators, etc., should include title and authority. Corporations should provide full name of corporation and title of authorized officer signing the proxy.

LOGO   Please separate carefully at the perforation and return just this portion in the envelope provided.  LOGO

LOGO

Annual Meeting of Proteostasis Therapeutics, Inc.

to be held on Monday June 29, 2020

for Holders as of April 30, 2020

This proxy is being solicited on behalf of the Board of Directors

VOTE BY:
              LOGO     INTERNET            LOGO     TELEPHONE

Go To

Call

www.proxypush.com/PTI

      866-286-3110
•

Cast your vote online 24 hours a day/7 days a week.

OR•

Use any touch-tone telephone toll-free 24 hours a day/7 days a week.

•

Have your Proxy Card/Voting Instructions Form ready.

LOGOMAIL

•


•

Have your Proxy Card/Voting Instruction Form ready.

Follow the simple recorded instructions.

•

View Meeting Documents.

          OR•

Mark, sign and date your Proxy Card/Voting Instruction Form.

•

Detach your Proxy Card/Voting Instruction Form.

•

Return your Proxy Card/Voting Instruction Form in the

postage-paid envelope provided.

The undersigned hereby appoints Meenu Chhabra and Janet L. Smart, and each or either of them, as the true and lawful attorneys of the undersigned, with full power of substitution and revocation, and authorizes them, and each of them, to vote all the shares of common stock of Proteostasis Therapeutics, Inc. which the undersigned is entitled to vote at said meeting and any adjournment thereof upon the matters specified and upon such other matters as may be properly brought before the meeting or any adjournment thereof, conferring authority upon such true and lawful attorneys to vote in their discretion on such other matters as may properly come before the meeting and revoking any proxy heretofore given.

THE SHARES REPRESENTED BY THIS PROXY WILL BE VOTED AS DIRECTED OR, IF NO DIRECTION IS GIVEN, SHARES WILL BE VOTED FOR THE ELECTION OF THE DIRECTORS IN PROPOSAL 1 AND FOR PROPOSAL 2. THE PROXIES WILL VOTE IN THEIR DISCRETION ON ANY OTHER BUSINESS AS MAY PROPERLY COME BEFORE THE MEETING AND ANY ADJOURNMENT THEREOF.

PROXY TABULATOR FOR

PROTEOSTASIS THERAPEUTICS, INC.

c/o MEDIANT COMMUNICATIONS

P.O. BOX 8016

CARY, NC 27512-9903

 

TABLE OF CONTENTS

LOGO   Please separate carefully at the perforation and return just this portion in the envelope provided.  LOGO

LOGO

Proxy for Annual Meeting of Stockholders to be held

on Monday June 29, 2020

This proxy is being solicited on behalf of the Board of Directors

Please vote, date and sign this Proxy on the other side and return it in the enclosed envelope.

The Stockholder signing on the reverse side (the “undersigned”), having received the Annual Report and Proxy Statement, hereby appoint(s) Meenu Chhabra and Janet L. Smart and each of them, Proxies of the undersigned (with full power of substitution) to attend the Annual Meeting of Proteostasis Therapeutics, Inc. (the “Company”) to be held on Monday June 29, 2020, and all adjournments and postponements thereof (the “Meeting”), and to vote all shares of Common Stock of the Company that the undersigned would be entitled to vote, if personally present, in regard to all matters that may properly come before the Meeting.

The undersigned hereby confer(s) upon the Proxies, and each of them, discretionary authority to consider and act upon such business, matters or proposals as may properly come before the Meeting.The Proxy, when properly executed, will be voted in the manner specified herein. If no specification is made, the Proxies intend to vote FOR all nominees for director in Proposal 1 and FOR Proposal 2.